ILRI challenge AnGR clippings

Innovation platform facilitation and assessment the focus of guidelines from ILRI


A manual by Pamela Pali and Kees Swaans on ‘Guidelines for innovation platforms: Facilitation, monitoring and evaluation’ was recently published by the International Livestock Research Institute (ILRI).

Innovation platforms have recently gained ground as a mechanism to help stimulate and support multi stakeholder collaboration in agricultural research for development. Generally, they are a mechanism to enhance communication and innovation capacity among mutually dependent actors, by improving interactions, coordination and coherence among all actors to facilitate learning and contribute to production and use of knowledge. It is anticipated that bringing different type of actors from the innovation system together for sharing experiences, knowledge, skills, ideas and resources contributes to economic gains through improved productivity and services by creating an enabling environment (i.e. supportive institutions and policies).

Prepared for a project on ‘sustainable management of globally significant endemic ruminant livestock of West Africa’ (PROGEBE), the manual draws on experiences in Guinea, Mali, Senegal and The Gambia.

More reports from the PROGEBE project


Filed under: Agriculture, Capacity Strengthening, CRP37, Gambia, Guinea, Indigenous Breeds, Innovation Systems, Livestock, Mali, Senegal, West Africa Tagged: innovation platforms, PROGEBE

Of mice (pupfish) and men: Existential matters rising in genetic rescues of endangered species

 ILRI's biorepository

Bio-repository of livestock genetic material at the International Livestock Research Institute (ILRI) (photo credit: ILRI/Susan MacMillan).

WIRED Magazine recently published an interesting article, ‘Attack of the mutant pupfish’, on some existential matters rising in attempts to make genetic rescues of endangered species. The author explores an interesting case study of the conflicting stands/approaches of animal conservationists serving as animal (species) preservationists and focusing on genetic integrity versus those serving as genetic managers or engineers focusing on genetic restoration.

This topic is of interest to a group of scientists at the International Livestock Research Institute (ILRI) who are collecting, characterizing, storing and promoting wider use of livestock genetic resources that are indigenous in developing countries. We can’t ‘save’ everything, so figuring out what to save, and how, is crucial.

‘. . . [W]hen an endangered species starts to really nose-dive, nature sometimes doesn’t move fast enough. One possible solution is to engineer hybrids. . . . This worry has plagued conservation for decades: Is the idea of “pure” or “pristine” nature even a useful conceptual tool?

Conservationists face what is in some ways as existential a threat as the one confronting the pupfish. The more they learn about nature, the more they wonder which part they’re supposed to conserve. . . .

‘Last summer at the Aspen Environment Forum, E. O. Wilson—arguably the world’s best-known conservation biologist—said that for human beings to maintain a viable environment on Earth, we should set aside half the planet’s surface for wild nature. But Emma Marris, a science writer and author of Rambunctious Garden, about human intervention in nature . . . pushed back.

Everything is already touched by human hands, she said. We have to manage it.

‘Wilson was aghast. “Where do you plant the white flag you’re carrying?” he asked.

‘Marris turned to a quote from ecologist Joe Mascaro: “I never took up arms,” she said. In fact, Marris and her husband, philosopher Yasha Rohwer, have found that more than 100 scientific papers treat the preservation of genetic integrity as some kind of manifestly obvious duty. But, they wrote, it ain’t necessarily so. Martin’s alternative: “genetic restoration,” in which organisms are given a fighting chance with new DNA. “Integrity” is irrelevant.

The future, then, will involve more intensive management of ecosystems and their inhabitants. That includes meddling not just in biogeography—what lives where—but in genes. There’s a delicate balance between saving a species and saving a gene pool, and calibrating it may be one of the biggest challenges of 21st-century conservation. . . .

‘“You need to do genetic restoration just as much as you need to do habitat restoration,” Martin says [Andy Martin is an evolutionary biologist at the University of Colorado at Boulder ] . . . . “But . . . the feeling is that genetic restoration is admitting defeat.”. . .

‘”It’s no longer just a biological question,” Martin says. “It’s an ethical, philosophical question. Because the fish won’t care.”

Read the whole article at WIRED Magazine: Attack of the mutant pupfish, Dec 2012.

With thanks to Luigi Guarino, senior scientist at the Global Crop Diversity Trust and curator of Agricultural Biodiversity Scoop.It!, where we found this article.

For more about ILRI’s animal genetic resources work, go here.

Tadelle Dessie at the ILRI ICARDA goat genetics resources training course

ILRI scientist Tadelle Dessie (right) leads a training course on methods and approaches on phenotypic characterization of animal genetic resources (goats), held in Addis Ababa, Ethiopia, 20-21 December 2012. The course was organized by ILRI and the International Center for Agricultural Research in the Dry Areas (ICARDA) (photo credit: ILRI/Liya Dejene).


Filed under: Article, Biotech, Genetics, Indigenous Breeds, PA, USA Tagged: WIRED Magazine

Women are the (invisible) guardians of livestock diversity–New FAO study

Ethiopia woman churning butter

Ethiopian woman churning butter the traditional way (photo credit: ILRI/Apollo Habtamu).

A new study by the Food and Agriculture Organization of the United Nations argues that to succeed, livestock breed conservation efforts must empower women.

‘Women livestock keepers worldwide must be recognized as the major actors in efforts to arrest the decline of indigenous breeds, crucial for rural food security and animal genetics, [the] new FAO study argues.

‘Yet women’s contribution to indigenous livestock breeding and conservation is poorly documented and undervalued, the study Invisible Guardians: Women Manage Livestock Diversity says.

‘Of the 600 million poor livestock keepers in the world, around two-thirds are women, whose men often have migrated to the cities. Women stay at home with the children and live by cultivating crops and keeping indigenous small stock such as chickens or goats, and perhaps a cow.

‘Indigenous breeds are adapted to often harsh local conditions, are disease resistant, thrive on easy to obtain local fodder or forage and generally take care of themselves. Such breeds may not produce a lot of meat, milk or eggs but they are low maintenance for run-off-their-feet poor rural women.

‘Such breeds are also a repository of irreplaceable genetic material. They often have traits such as disease-resistance that can be important for breeding programmes. And in a world threatened by climate change, breeds that are resistant to drought, extreme heat or tropical diseases are of major potential importance.

‘Problems may arise when projects or national authorities try to introduce exotic breeds or cross-breeds to try to increase production of meat, milk and eggs to meet booming worldwide food demand. These animals need special and often expensive feed, wait to be fed rather than foraging on their own, need expensive veterinary care and cannot survive prolonged drought or other extreme weather.

‘Poor rural livestock keepers, and women in particular, are often unable to obtain the inputs or spare the time needed to raise these animals successfully. In case such breed introductions and production intensification are successful and livestock becomes an important source of cash income, women often lose their role as livestock keepers.

‘The advantages of indigenous breeds have been long known. But the FAO study asserts that the role of women in safeguarding and defending indigenous breeds and improving their genetics through careful breeding has not been appreciated.

Women are the guardians of livestock diversity, says study author Ilse Köhler-Rollefson.

‘Meanwhile, according to the latest figures, about 22 percent of the world’s livestock breeds are still classified as being at risk of extinction, although breed population figures are often unreported or out of date, making the true state of livestock diversity difficult to estimate.

‘Countries are beginning to put programmes into place to reverse the alarming decline in the numbers of indigenous livestock breeds. The new study suggests that these initiatives will not be successful if women’s role as keepers of indigenous livestock is not taken into account. Women have to be the central players in such conservation campaigns, the study says, and to ensure that they are, more groundwork needs to be done.

The report recommends that gender issues are made central to projects, programmes and policies that focus on animal genetic resource management.

‘The following actions among others should be taken at the project level:

  • ‘Collect gender- and age-disaggregated data and investigate the rights, needs, roles and responsibilities of women during surveys and before embarking on any project related to animal genetic resources.
  • ‘Design extension, training and the introduction of new technologies so that they are accessible to women.
  • ‘Investigate family structures and how they affect the ability of women to act and interact.
  • ‘Investigate specific problems that women have in accessing markets for their animal products.

If governments really want their conservation programmes to bear fruit, they can:

  • ‘Conduct economic studies of keeping locally adapted vs improved breeds.
  • ‘Ensure that poor herders have sufficient access to common property like grazing lands.
  • ‘Inform banks about the importance of providing credit to rural women and about the benefits of indigenous breeds; banks currently tend to lend to male farmers and people who want to stock improved breeds.
  • ‘Support value-chain development for products from indigenous breeds as a means of creating income opportunities for rural women and reviving local economies.

‘International agencies can back up national efforts to empower women livestock keepers by collecting and disseminating gender-disaggregated data and putting the issue on the global agenda in appropriate forums.’

Read the news release at the FAO Media Centre: Women are main guardians of crucial livestock diversity, 5 Nov 2012, or the full report: Invisible Guardians: Women Manage Livestock Diversity, Nov 2012.

See also Strategy and plan of action to mainstream gender at ILRI, ILRI Policy Brief, April 2012, or the whole report: Strategy and Plan of Action to Mainstream Gender at ILRI. Nairobi: International Livestock Research Institute, Mar 2012.

And see Livestock and Women’s Livelihoods: A Review of the Recent Evidence, ILRI Discussion Paper No. 20, by Patti Kristjanson, Ann Waters-Bayer, Nancy Johnson, Anna Tipilda, Jemimah Njuki, Isabelle Baltenweck, Delia Grace and Susan MacMillan. Nairobi: International Livestock Research Institute, 2010.

See also this week’s blog post by CGIAR director general (WorldFish Center) Stephen Hall: Reflections on gender transformative research, 5 Nov 2012.

Watch this 4-minute video narrated by former ILRI gender expert Jemimah Njuki: Working with and for women and livestock, 2011.

And the 13-minute video in, Farm Animals Can Help Millions of Women Raise the Well-being of Their Households and Communities,which ILRI scientist Jemimah Njuki argues for using animal agriculture to help redress skewed resources available to rural women worldwide. In societies where women are unable to own anything else, farm animals provide women with incomes. And when those women’s incomes rise, the health, nutrition and education of their whole families also rise, with everybody winning.


Filed under: Animal Breeding, Biodiversity, Film and video, Indigenous Breeds, Launch, PA, Women Tagged: FAO, Ilse Kohler-Rollefson

Kenyan Bridgit Muasa on cross-breeding ‘supercows’ for Africa

Watch ‘The Importance of Livestock Production in Kenya’, a short (3:12) filmed interview by FarmingFirst at Rio+20 of 2010 AWARD Fellow Bridgit Muasa, a Kenyan livestock breeding specialist mentored by ILRI scientist Karen Marshall.

Bridgit Muasa, from Kenya, is a veterinary officer with the Kenya Ministry of Livestock Development. She has been mentored in the African Women in Agricultural Research and Development (AWARD) professional development program by Karen Marshall,  a scientist in animal breeding and quantitative genetics working at the Nairobi headquarters of the International Livestock Research Institute (ILRI).

‘Livestock management in Kenya is often left to the women, who manage the animals’ day-to-day health and production’, says Muasa, who is working on improving the delivery of farm animal genetic resources via assisted reproductive technologies as a research assistant at ILRI.

Muasa says that livestock are a crucial aspect of millions of livelihoods in Kenya. She says Kenya has 14 million indigenous cattle and 3 million genetically improved exotic breeds of cattle. Her research is breeding cattle that are both highly productive, like exotic breeds, and resilient to harsh weather conditions, like Africa’s native breeds.

Muasa conducts research on reproductive technologies to improve animal genetic resources, particularly evaluation of the Boran cow as a potential donor of oocytes for in vitro embryo production.

One of the ways we’re trying to address this is by building a sort of “supercow” by breeding exotic cows with indigenous cows, and so getting the best attributes from each. For this we use the technology in vitro embryo production, which is essentially like test-tube babies; so now we have test-tube cows.

Muasa holds a BSc in veterinary medicine and a master’s in clinical studies in theriogenology from the University of Nairobi. She plans to pursue a PhD in livestock development with an emphasis on improving livestock genetic resources. She was interviewed on film on 14 Jun 2012 at the Rio+20 United Nations Sustainable Development conference. The filmed interview is part of a FarmingFirst TV series.

Muasa is one of 250 African woman scientists who have won an AWARD Fellowship. AWARD strengthens the research and leadership skills of African women in agricultural science, empowering them to contribute more effectively to poverty alleviation and food security in sub-Saharan Africa. For more information, please visit www.awardfellowships.org


Filed under: Animal Breeding, Biotech, Biotechnology, East Africa, Event, Film and video, Genetics, ILRI, Indigenous Breeds, Interview, Kenya, PA, Staff Tagged: 2012Rio+20, 2012RioPlus20, AWARD, Bridgit Muasa, Karen Marshall, Kenya Ministry of Livestock Development, Rio4Ag

Small livestock, big impact

 Presenters Lydia Wamalwa (CIP) and Sheila Ommeh (ILRI-BecA)

Kenyan geneticist and new PhD Sheila Ommeh (right) works at the Biosciences eastern and central Africa Hub (BecA Hub) and ILRI’s animal health laboratories in Nairobi, Kenya, studying Africa’s native chicken breeds (photo credit: ILRI/Susan MacMillan).

‘Sheila Ommeh, a poultry geneticist at the International Livestock Research Centre in Nairobi, hopes to introduce a disease-resistant chicken that can be easily reared by women farmers.

‘The humble chicken may be a small bird but it could play a big role in reducing rural poverty in Africa, particularly among women farmers. . . .

‘Ommeh knows a thing or two about chickens, having grown up on the slopes of Mount Elgon in western Kenya where most homes rely on poultry flocks for food and income.

‘Her mother, aunts and grandmothers all kept chickens and the birds even paid for some of her schooling.

‘Three quarters of rural households in Kenya rear poultry, which is a cheap source of good protein. These smallholders are mostly women.

‘But Ommeh has seen first-hand how virulent diseases like Newcastle and Gomboro can wipe out flocks and destroy families’ livelihoods, increasing hunger and forcing parents to pull their children out of school because they can’t afford to pay for it. . . .

‘Although women produce most of the food consumed in Africa, only one in four agricultural researchers are female and even fewer hold leadership positions in African agricultural research institutions.

‘One organisation trying to close this gap is African Women in Agricultural Research and Development (AWARD), which is helping women like Ommeh build their technical and leadership skills. . . .

‘Ommeh, who holds a PhD in chicken genetics, firmly believes that the answers to Africa’s problems lie within Africa.

In my view … it’s about time Africa looked for solutions in Africa for Africa,” she told TrustLaw, during a trip to London to address a group of British MPs about empowering African women scientists.

‘. . . The 34-year-old scientist believes it should be possible to produce a disease-resistant breed that weighs around 4 kilogrammes and produces 250 eggs a year – about three times the weight and yield of indigenous chickens. . . .

Chicken is a small livestock but I believe it has the capacity to have a big impact.”. . .’

Read the whole article at TrustLaw: Designer chicken could help empower Africa’s rural women, 07 Mar 2012.


Filed under: Animal Breeding, Animal Diseases, Animal Health, BecA, Biodiversity, Biotech, Disease Control, East Africa, Event, Genetics, ILRI, Indigenous Breeds, Kenya, PA, Poultry, Vaccines, Women Tagged: AWARD, Chickens, Sheila Ommeh, TrustLaw

Changing the face of agriculture in Africa–one (emerging woman) leader at a time

 Sheila Ommeh presents

CGIAR AWARD Fellow Sheila Ommeh, working at ILRI-BecA, gives a presentation on the importance of conserving and better using Africa’s native chicken breeds for World Bank vice president Rachel Kyte on 2 Feb 2012 at the World Agroforestry Centre (photo credit: ILRI/Susan MacMillan).

The Huffington Post this week carries a blog by Sir Gordon Conway, professor of international development at Imperial College London, who says that African governments and those that work with them need to make women a much higher priority. As an example of how much difference African women can make, he cites recent statistics from the United Nations Food and Agriculture Organization (FAO) and the work of Sheila Ommeh, an AWARD Fellow and chicken geneticist working at the Biosciences eastern and central Africa Hub (BecA Hub) of the International Livestock Research Institute (ILRI), in Nairobi, Kenya.

Sheila Ommeh is passionate about poultry. A PhD fellow at the International Livestock Research Institute, based in Nairobi, Kenya, Sheila hopes to introduce a disease-resistant chicken using indigenous breeds that can be easily produced by women farmers.

Sheila has a home grown understanding of the importance of poultry farming to the rural poor. Her mother and grandmother raised chickens to support the family’s children. But disease prevalence was high and the flock was wiped out on occasion. When the chickens died, money for food and school fees was in short supply. Sheila grew up determined to help find a solution.

‘The majority of those who produce, process, and market food in Africa are women. Furthermore, according to the FAO’s 2010–11 State of Food and Agriculture report, women make up, on average, 50 percent of the agricultural labor force in sub-Saharan Africa.

‘Nevertheless, only one in four (25 percent) agricultural researchers in Africa is female. Even fewer, one in seven (14 percent), hold leadership positions in African agricultural research institutions.

‘So how can we ensure that Africa’s agricultural science and research is really focused on the needs of those who feed the world?

‘African Women in Agricultural Research and Development (AWARD) is a ground-breaking career-development program that helps female agricultural researchers to build their technical and leadership skills. The 250 women in AWARD come from 11 different countries, and share one common goal: to change the face of agriculture in Africa. . . .

‘In 2008, Sheila won a fellowship from AWARD to help realize her ambitions. On March 7—on the eve of International Women’s Day—you can hear more of her story, alongside other speakers from AWARD, the International Institute for Environment and Development, Oxfam GB, and the Bill & Melinda Gates Foundation. Agriculture for Impact is working with AWARD and the All Party Parliamentary Group on Agriculture and Food for Development to convene the panel discussion on “Effective Solutions for Agricultural Development through Empowered Women Scientists.” . . .

Read the whole blog post at the Huffington Post: Who feeds the world? (Girls), 2 Mar 2012.

Read about Ommeh’s presentation in Feb 2012 to World Bank vice president Rachel Kyte: World Bank vice president Rachel Kyte in Nairobi town hall on ‘big picture agriculture’, 2 Feb 2012.

About Sheila Ommeh
Thirty-four-year-old Ommeh grew up on the slopes of Mount Elgon in western Kenya where indigenous chicken is a popular staple food for the rural community and where local breeds are reared mostly women and children. Newcastle and other viral diseases and the looming threat of bird flu threaten livelihoods of these small-scale poultry producers, and can lead to increased hunger and poverty. The focus of Ommeh’s recent PhD was a search for candidate chicken genes controlling for resistance, tolerance or susceptibility to chicken viral diseases such as bird flu and Newcastle disease, which to date have no cure or vaccine. Her long-term aim is to help build a genetically improved chicken breed that will be resistant to disease and easily adopted by the rural community.

In August 2008, Ommeh was among 60 African women scientists selected from more than 900 candidates in nine countries to receive an “African Women in Agricultural Research & Development” (AWARD) Fellowship for 2008–2010. AWARD is funded by the Bill and Melinda Gates Foundation and managed by the Gender and Diversity (G&D) program of the CGIAR.


Filed under: Africa, BecA, Biodiversity, Biotech, Capacity Strengthening, Event, Genetics, ILRI, Indigenous Breeds, Kenya, Opinion piece, PA, Poultry, Women Tagged: All Party Parliamentary Group on Agriculture and Food for Development, AWARD, BMGF, FAO, G&D Program, Huffington Post, IIED, International Women's Day, Oxfam GB, Sheila Ommeh, Sir Gordon Conway

Building capacities in animal genetic resources – a ‘training of trainers’ approach

Since 1999, the International Livestock Research Institute (ILRI)  has partnered with the Swedish University of Agricultural Sciences (SLU) to provide capacity building on the sustainable use of Animal Genetic Resources (AnGR).

This report by Julie Ojango, Birgitta Malmfors, Okeyo Mwai, and Jan Philipsson on Training the trainers – An innovative and successful model for capacity building in animal genetic resource utilization in Sub-Saharan Africa and Asia was released by ILRI and SLU on 31 December 2011.

Scientists from 46 developing countries in sub-Saharan Africa and Asia have been trained on animal breeding and genetics developments, implementation of breeding strategies, and on teaching and communication methods.

Livestock accounts on average for about 30% of the agricultural GDP in developing countries, yet the productivity of many livestock populations is inadequate due to a complexity of factors. The genetic variability between and within species and breeds is largely unexploited at the same time as a continuous loss of genetic diversity takes place. Livestock productivity must increase to meet the projected demand for doubled meat and milk production within a few decades in developing countries, while minimizing environmental impact. These challenges require highly skilled people to lead the development in the desired direction. Unfortunately, developing countries suffer from a shortage of trained people, not least in the area of animal breeding and genetics, both at research and higher education institutions and in organizations responsible for livestock development.

It is in this context that the ILRI-SLU project has developed its philosophy of ‘training the trainers’ to effectively multiply knowledge and concepts to new generations of students, researchers and policy makers. This synthesis report provides insights and reflections on the project’s outputs and outcomes, and informs on the ways forward in terms of further investment in developing and strengthening human capacity in the field of AnGR.

Download the research report

More on this topic:


Filed under: Africa, Animal Breeding, Asia, Biodiversity, Biotech, Capacity Strengthening, ILRI, Indigenous Breeds, Livestock, Report, Research Tagged: AnGR, SLU

The Gambia’s hardy native ruminant livestock surveyed in bid to improve their conservation and productivity

Although livestock play a central role in rural development in West Africa, traditional livestock systems have high death rates, low reproductive rates and low offtake rates. Furthermore, the presence of trypanosome-infected tsetse flies in the sub-humid and humid areas hurts the potential for livestock production. The region’s endemic ruminant livestock, however, are highly adapted to the local environmental conditions and are able with minimal inputs to remain productive in tsetse-infested areas where other breeds cannot survive. The conservation and improvement of these native African breeds has potential to greatly improve the livelihoods of West Africa’s livestock keepers.

A project named ‘Sustainable Management of Globally Significant Endemic Ruminant Livestock in West Africa’ (or ‘PROGEBE‘, an acronym of the French version of the project title) aims to develop models for community-based conservation and management of critical habitats for three endemic ruminant livestock breeds—N’Dama cattle, Djallonké sheep and West Africa Dwarf goats—and to develop strategies for preserving their unique genetic traits/habitats.

A research report by Karen Marshall, Maria Ejlertsen and Jane Poole of the International Livestock Research Institute (ILRI), on Sustainable management of globally significant endemic ruminant livestock in West Africa (PROGEBE): Estimate of livestock demographic parameters in the Gambia was released by ILRI on 20 Dec 2011.

This report describes the results of a 12-month retrospective survey for estimating livestock demographic parameters of endemic ruminant livestock kept by smallholders in The Gambia. The demographic parameters estimated included natural rates, such as parturition, prolificacy and mortality rates, as well as management rates, such as offtake and intake rates.

The 12-month retrospective survey, covering the period between mid-November 2008 and mid-November 2009 and carried out in November 2009, is one of several baseline surveys being conducted by the PROGEBE project in The Gambia; 29 cattle herds (of mostly the ancient West African N’Dama breed), 83 sheep flocks (mostly Djallonké) and 92 goat herds (mostly of West African Dwarf) were surveyed.

The results of the survey suggest there is considerable scope for improvement of demographic parameters through improved herd/flock management in the short term and breeding strategies in the long term. The single most striking result is the natural mortality rate, which was found to be very high for cattle less than one year of age and for sheep and goats across all age groups.

Download the research report


Filed under: Africa, Animal Breeding, Animal Production, Biodiversity, Biotech, Cattle, Gambia, Goats, ILRI, Indigenous Breeds, Livestock, Project, Report, Research, Sheep, Small Ruminants, West Africa Tagged: Gambia, Karen Marshall, PROGEBE

Protecting livestock breeds for people

Goat on verandah in Berhampur, India

Livestock are ubiquitous in the developing world. The ‘big five’—cattle, sheep, goats, poultry and pigs—as well as 9 other popular farm animals and 26 or so more specialized species are raised by more than half a billion people either on pastoral rangelands by nomadic herders, or on mixed farms by smallholders who raise crops along with livestock, or in peri-urban areas by people who raise a few animals in their backyards. All of these small-scale livestock enterprises matter to developing-country governments because livestock account for some 30 per cent of their agricultural gross domestic product, a figure expected to rise to 40 per cent by the year 2030.

The diverse livestock production systems, like most crop production systems, are changing in response to globalization, urbanization, environmental degradation, climate change and science and technology. But the fastest changes are occurring within the livestock systems. That’s because the developing world’s rising human populations and household incomes are causing demand for milk, meat, eggs and other livestock foods to soar. As one would expect, livestock markets are growing and changing to serve that growing demand. What’s less appreciated are the changes being wrought by many of the billion-plus small-scale livestock keepers and sellers of the developing world who are changing the way they do business to help meet that growing demand. The rate of change within the livestock sector is so rapid that many local populations of livestock developed by small-scale farmers over millennia no longer have time to evolve adaptations to their new circumstances or the new needs of their owners. They are simply dying out, and at unprecedented and accelerating rates.

The Food and Agriculture Organization of the United Nations estimates that on average a breed disappears every month and that 20 per cent of our uniquely adapted breeds of domestic animals are at risk of extinction. Over the last 150 years, farmers in industrialized countries supplanted their indigenous farm animals with a few high-producing breeds of a few species (chickens, pigs, cattle) suited to highly intensified production systems. The result is that 70 per cent of the world’s known livestock genetic diversity now resides on small farms and in remote regions of developing countries. With all the challenges facing developing countries and their one billion people living on less than a dollar a day, the question arises as to what immediate practical and cost-effective steps could be taken to preserve the wealth of their livestock genetic diversity. From a research viewpoint, it’s clear that if we’re going to manage the world’s remaining livestock genetic resources well, we’ll have to characterize the remaining populations to decide which are worth saving and why, we’ll have to find ways of broadening use of those populations deemed useful, and we’ll have to conserve the most important livestock genetic diversity for possible future use—by poor and rich farmers alike.

Discover more about this topic:


Filed under: Animal Breeding, Biodiversity, Genetics, Indigenous Breeds Tagged: breeds

Tackling poultry diseases in Ethiopia

Developing countries such as Ethiopia have many indigenous chicken varieties which are well adapted to local environments as they are excellent foragers, better able to avoid predator attacks and demonstrate better immunity to common diseases. However, due to relatively low genetic potential and poor levels of husbandry, most of these indigenous chicken breeds grow slowly and are poor producers of small sized eggs. Furthermore, infectious diseases have a major impact and prevent even this limited genetic potential from being realised. Breeding programs using local chicken ecotypes suggest rapid improvement in productivity is possible. However, these programs are yet to select for resistance to infectious disease.

The ‘chicken health for development‘ project in Ethiopia aims to develop a poultry breeding program to improve resistance to priority infectious diseases whilst enhancing productivity and production.

Project researcher Stacey Lynch recently published this video on the work of the project as it works with communities to sample local chickens for diseases and genetic resistance …

 

 

Read a related issue brief on chicken research for development by project scientist Tadelle Dessie …


Filed under: Africa, Animal Breeding, Animal Diseases, Biotech, Disease Control, East Africa, Epidemiology, Ethiopia, ILRI, Indigenous Breeds, Livestock, Poultry, Project, Research Tagged: ch4d

Researching trypanotolerance in indigenous cattle breeds of Ethiopia

 ParticipantsBetween 15 and 17 November 2011, scientists, experts and development practitioners from the Ethiopian Ministry of Agriculture, universities and non-governmental and international organizations gathered in Addis Ababa to share research results on trypanotolerance in indigenous local cattle breeds in Ethiopia (Sheko, Abigar, Horro and Gurage) and experiences with community-based sheep breeding.

The Sheko breed got high attention in the workshop.  It is small in number – almost endangered – yet highly trypanotolerant in tsetse infested areas, but communities are reluctant to adopt the Sheko breed because of its endangered status.

Participants discussed how the potential of the Sheko breed could be exploited. First, by breeding to preserve its unique characteristics that can improve the productivity of stallholders in tsetse infested areas of Ethiopia, second, to alter community perceptions on the breed.

Following some presentations, participants formed groups to discuss two topics: sheep breeding and tryps control. Key issues emerging from the groups were the need to develop a central database, scale-up community-based sheep breeding programs, market strategy, capacity building and mobilization of communities ,and development of an integrated national trypanosomosis control strategy.

On the last day of the workshop, a small group formed to develop and submit a sheep breeding and tryps control concept note and action plans to the Ministry of Agriculture.

Jan Philipsson from the Swedish University of Agricultural Sciences reflects on the meeting:

The workshop was organized by the International Livestock Research Institute (ILRI), the Ethiopian Institute of Agricultural Research (EIAR), and the Swedish University of Agricultural Sciences (SLU).

Photos on flickr

Powerpoint presentations on Slideshare

Video interview with Okeyo Mwai (ILRI)


Filed under: Agriculture, Animal Breeding, Animal Diseases, Animal Production, Biodiversity, Biotech, Biotechnology, Ethiopia, ILRI, Indigenous Breeds, Livestock, Sheep, Small Ruminants Tagged: Abigar, cattlebreedsr4d, EIAR, Gurage, Horro, sheep, sheko, SLU

Information systems on domestic animal genetic resources

For the November 2011 ‘liveSTOCK Exchange’ event at ILRI, Tadelle Dessie, Yetnayet Mamo and Okeyo Mwai prepared an issue brief on the Domestic Animal Genetic Resources Information System (DAGRIS) …

In developing countries, lack of accurate information on the diversity and status of existing farm animal genetic resources is believed to exacerbate the alarming rate of
irreversible loss of genetic diversity. Such losses reduce opportunities to improve food security, alleviate poverty and attain sustainable agricultural practices.

DAGRIS (http://dagris.ilri.cgiar.org) is an electronic source of systematic information on indigenous farm animal genetic resources. Initial development of the system focused on three priority farm animal species in Africa – cattle, sheep and goats. It was subsequently expanded to include other livestock species (chicken, pigs, buffalo and yak) and developing countries in Africa and Asia.

Download Issue Brief 9.

On 9 and 10 November 2011, the ILRI Board of Trustees hosts a 2-day ‘liveSTOCK Exchange’ to discuss and reflect on livestock research for development. The event will synthesize sector and ILRI learning and help frame future livestock research for development directions.

The liveSTOCK Exchange will also mark the leadership and contributions of Dr. Carlos Seré as ILRI Director General.  See all posts in this series / Sign up for email alerts


Filed under: Animal Breeding, Biodiversity, Biotech, ILRI, Indigenous Breeds, Knowledge & Information, Livestock, Report, Research Tagged: dagris, livestockX

Livestock genetic resources of and for the poor: Where ILRI research stands

For the November 2011 ‘liveSTOCK Exchange’ event at ILRI, Okeyo Mwai, livestock geneticist, reflects on ILRI’s research over the past decade on the animal genetic resources of the developing world and future directions.

Watch the 2-minute interview with Okeyo Mwai.

What we achieved in the last decade
With the Food and Agriculture Organization of the United Nations and many other partners, local as well as international, we achieved:

> Greater public understanding of the value of Africa’s indigenous livestock genetic resources through assessments and articulations of their global ‘meltdown’ in recent decades and the causes for this.

> Greater understanding by policymakers that the best way to conserve this important ‘barnyard diversity’ is to make greater use of native breeds, populations and genes on farms—and that implies providing the farmers both with the animal stock and with incentives for maintaining them.

> Greater scientific understanding of the rich storehouse of genetic potential that has evolved in indigenous livestock that may be used to help people cope with a more extreme and unpredictable climate in future.

What we learned in the last decade
> International agreements on actions urgently needed to conserve and improve the animal genetic resources of the developing world don’t necessarily translate into funding to get the job done.

> High-level declarations and agreements do not translate easily into national and regional programs, and the latter often diverge in their perspectives and approaches.

What were the challenges?
> Encouraging developing countries to embrace smart ways of bio/gene banking selected populations of their indigenous livestock.

> Helping national and regional organizations to make more and better use of current science and good practice in the conservation and use of their livestock genetic resources.

> Obtaining sufficient funds to conduct livestock breeding research with real impacts in developing countries.

What were some outcomes?
> ILRI’s significant scientific presence and messages, keynote paper given by Carlos Seré, and strong media outreach at an FAO conference on animal genetic resources in Interlaken, Switzerland, in 2007.

> ILRI’s high-profile John Vercoe Conference on Animal Breeding for Poverty Alleviation in 2007.

> ILRI’s significant contributions to a 2011 Special Issue on Animal Genetic Resources in Livestock Science.

> Livestock breeding strategies added to ILRI research agenda.

> In vitro reproductive technology platforms developed and protocols adapted; successful production of in vitro calves.

Current situation
> Need to continue pushing for better and more integrated and comprehensive phenotyping and data collection on breed performance, genomics and bioinformatics using innovative IT applications and geographic information systems.

> Need to invest more in quantitative-genomic expertise and to focus on designing productive research-to-development projects and building capacity of developing countries to do this work.

Future directions
> In the face of rapidly disappearing livestock breeds and genes in developing countries, build a phenotypic and genomic livestock database and well-documented bio/gene banks for use by scientists in future, who one day may be able to replicate breeds that have disappeared.

> Embrace emerging sciences such as livestock genomics and bioinformatics and comparative reproductive technologies as integral and significant parts of ILRI’s research program and become the partner of choice and a reference institution in the area of animal genetic resources.

Contributed by Okeyo Mwai, Team Leader in ILRI’s Biotechnology Theme.

On 9 and 10 November 2011, the ILRI Board of Trustees hosted a 2-day ‘liveSTOCK Exchange’ to discuss and reflect on livestock research for development. The event synthesized sector and ILRI learning and helped frame future livestock research for development directions.

The liveSTOCK Exchange also marked the leadership and contributions of Dr. Carlos Seré as ILRI Director General. See all posts in this series / Sign up for email alerts


Filed under: Animal Breeding, Biotech, East Africa, Event, Film and video, Genetics, ILRI, Indigenous Breeds, Kenya, Sheep, Small Ruminants, Staff Tagged: 2011 Livestock Xchange Conference (ILRI Addis), livestockX, Okeyo Mwai, Red Masai sheep

Characterization and conservation of indigenous sheep genetic resources

A research report by Solomon Gizaw, H. Komen, O. Hanotte, J.A.M. van Arendonk, Steve Kemp, Aynalem Haile, O. Mwai and Tadelle Dessie on Characterization and conservation of indigenous sheep genetic resources: A practical framework for developing countries was released on 12 April 2011.

Livestock characterization projects in developing regions are characterized by a mere physical description of traditionally recognized populations or a purely academic genetic description of populations. However, characterization of livestock resources is meant to serve the purpose of developing conservation and utilization programs. A national characterization project should be geared to the specific national livestock production objectives. Thus there is a need to adopt a more practical characterization approach to assist in the development of national conservation and utilization strategies.

This report provides a practical methodological framework for the characterization and conservation of sheep resources in developing regions.

The report highlights current approaches and tools for characterization and conservation of sheep resources and presents a model approach that synthesises the results of a study on characterization and conservation of sheep resources in Ethiopia. The methodological framework can be applied elsewhere in developing countries with similar characterization and conservation objectives.

The report largely focuses on the technical aspects of sheep genetic resource characterization and conservation in developing regions. Operational aspects of setting up national programs for characterization and conservation action may be country specific. However, some general aspects such as institutional setups and breeding policy and strategy formulation could be similar across countries. A proposed scheme for setting up a national livestock characterization and conservation program is presented, taking Ethiopia as a case study.

Download the paper


Filed under: Africa, Biodiversity, East Africa, Ethiopia, ILRI, Indigenous Breeds, Livestock, Report, Research, Sheep, Small Ruminants Tagged: Animal genetic resources

FAO to finance national projects enhancing livestock diversity

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Livestock genetic diversity is key to global food security; this is the native black pig of the mountainous region of northern Vietnam (photo on Flickr by Rock Portrait Photography).

‘Germany, Norway and Switzerland have contributed a first donation of $1,000,000 to a new, FAO [United Nations Food and Agriculture Organization]-managed fund designed to help developing countries conserve and sustainably use their livestock breeds.

‘The fund will provide financing for individual projects submitted by countries in support of the internationally-agreed Global Plan of Action for Animal Genetic Resources. The plan, adopted by all FAO member countries in 2007, has become a key instrument for the conservation and sustainable use of animal genetic resources at global, regional and national level.

‘Any developing country may put forward projects for financing by the fund, which is due to become operational in September. “The money will be disbursed on the basis of letters of agreement between applicant countries and FAO, following an innovative, transparent and impartial selection process led by FAO’s Commission on Genetic Resources for Food and Agriculture,” says Linda Collette, the Secretary of the Commission.

‘Some 21 percent of the world’s more than 8000 livestock breeds are classified as at risk of extinction. But since the Global Plan of Action went into force, countries’ reporting on breeds’ population status is improving and points to a slowing of the reported rate of extinction. . . .

‘A wide portfolio of animal genetic resources is crucial to adapting and developing agricultural production systems to meet the challenges of climate change and growing world population. Other contributions to the fund will be needed from different sources, including from the private sector.’

Read whole article at the Media Centre of the United Nations Food and Agriculture Organization: New fund for livestock biodiversity management at FAO: Will offer grants to developing countries, 21 Jul 2011.

And watch a new 15-minute film by ILRI: Livestock under threat: Managing the future of native West African ruminant livestock, 29 Jun 2011.


Filed under: Animal Breeding, Biodiversity, Film and video, Genetics, Indigenous Breeds, PA Tagged: FAO

Backyard poultry keeping and poverty reduction in South Asia: Good practices and good returns

Chicken, dung and farm cart in West Bengal, India

A chicken forages beneath a farm cart in Brahampur (Arwa Village), in West Bengal, India, near drying patties of cow dung that will be used as cooking fuel (photo credit: ILRI/Mann).

A South Asia Pro-Poor Livestock Policy Programme, a joint initiative of the National Dairy Development Board of India and the United Nations Food and Agriculture Organization, has identified and documented a range of good practices along the poultry supply chain in Bangladesh, Bhutan and India. These include interventions related to the provision of inputs, management and improved husbandry practices, health service delivery and the marketing of live birds and eggs.

This paper reviews and draws lessons out of 11 good practices on small‐scale poultry farming, documented by the programme in collaboration with a variety of public and private actors, including national and state governments, non-governmental organizations and private companies. The document attempts to identify gaps—in the current policy and institutional framework in Bangladesh, Bhutan and India—to enable improvements in smallholder poultry rearing.

The economics of South Asia’s backyard and small-scale poultry farming are interesting. Among other matters, we learn from this publication:

‘Returns on a one‐year investment in one single hen in scavenging and semi‐scavenging systems are handsome, averaging about 285 per cent and providing an average annual net income of about US$ 40 in India, that is, about 34 per cent of the national rural poverty threshold. These include eggs laid and consumed/sold, chicks hatched and birds consumed and sold.

‘In backyard production systems, investments in nondescript and indigenous birds, such as the Aseel and the Kadaknath, provide higher returns than investments in exotic ones, because of the high cost of feed for exotic birds (which are not good scavengers) and the lower market price of exotic meat and eggs (which are not preferred by rural consumers). . . .

‘The larger the flock size, the smaller the return on investments and the profit per bird, most likely because of the growing feed and animal health costs, which are minimal, if any, in backyard poultry farming system. In effect, commercial and semi‐commercial poultry enterprises are characterized by high‐volumes and low‐profit margins per bird. The implication is that backyard and small‐scale poultry farms are viable enterprises only as far as the scavenging base is sufficient to feed the birds.

‘Keeping a few exotic birds makes little economic sense because it is more profitable to raise a few nondescript or indigenous birds that can thrive almost on their own. At the same time, when the scavenging base is limited, it is sounder to keep just one or a few local birds rather than a flock of say ten local hens because the cost of additional feed will be higher than the returns from the hens. . . .’

Read the whole publication at the website of the South Asia Pro-Poor Livestock Policy Programme.


Filed under: Bangladesh, CRP2, India, Indigenous Breeds, PA, Policy, Poultry, Pro-Poor Livestock, Report, South Asia Tagged: Bhutan, FAO, India National Dairy Development Board, Pro-Poor Livestock Policy Programme (India)

Australian TV program highlights research in race against time to save Africa’s ‘hairless sheep’ and other native breeds

Disease-resistant red Maasai sheep in Kenya

Worm-resistant red Masai sheep, an indigenous ‘hairless’ sheep kept by Maasai herders, in Kenya (photo credit: ILRI).

Catalyst, the Australian Broadcasting Company’s well-regarded science television program, yesterday (14 Jul 2011) broadcast an episode on research being conducted in Kenya to conserve the native livestock of Africa.

Okeyo Mwai, an animal geneticist working at the International Livestock Research Institute (ILRI), gives Catalyst’s Paul Willis an overview of some of Africa’s livestock treasures, including East Africa’s big-horned and beautiful Ankole cattle, the hardy and drought-resistant Boran cattle, and a ‘hairless’ and worm-resistant red Masai sheep. While the red Masai sheep produces no wool, this fast-disappearing breed possesses a genetic resistance to intestinal worms, a trait of intense interest to sheep breeders across Australia and the rest of the world, who still have to deworm their sheep on a regular and costly basis.

Africa has some 150 native breeds of cattle alone, says Mwai. And they are disappearing at a rapid rate, and along with them, the genes they carry that could help humankind feed itself in the coming decades in the face of major climate and other changes.

Mwai has been working for two decades to help local farmers reap the benefits of reintroducing old breeds into new herds. He tells Willis: ‘Our job is to race against time, not to lose the genes that are already there. . . .’

Willis concludes the program by reminding his audience that Africa’s livestock genetic treasure-house matters to us all: ‘By pinning down these valuable indigenous genes before they become extinct, researchers hope to bring a bit of Red Masai toughness to sheep across the globe.’

Watch the 6-minute program: ABC Catalyst: African livestock, 14 Jul 2011.


Filed under: Animal Breeding, Animal Diseases, Biotech, Cattle, East Africa, Film and video, Genetics, ILRI, Indigenous Breeds, Kenya, PA, Sheep, Small Ruminants Tagged: Catalyst TV (Australia), Crawford Fund, Okeyo Mwai, Red Masai sheep

Commission on Genetic Resources for Food and Agriculture to review progress in animal genetic resources

The Thirteenth Session of the Commission on Genetic Resources for Food and Agriculture will be held at FAO Headquarters in Rome from 18 – 22 July 2011.

It will review progress made in the implementation of the Global Plan of Action for Animal Genetic Resources. The following agenda items / documents are of particular relevance to animal genetic resources:


Filed under: Animal Breeding, Animal Production, Biodiversity, Biotechnology, Indigenous Breeds, Livestock Tagged: CGRFA, FAO

Our ‘food ark’ is in trouble, says National Geographic Magazine

Jean Hanson shows Cary Fowler ILRI's Genebank in Addis Ababa

In ILRI’s Forage Genebank on the ILRI campus in Addis Ababa, Cary Fowler, executive director of the Global Crop Diversity Trust, and Jean Hanson, former head of ILRI’s Genebank, examine seed that was sent a few years ago for safe duplicate storage in the Svalbard Global Seed Vault, located in the Norwegian Arctic Circle (photo credit: ILRI/Mann).

The cover story of the current issue of National Geographic says a food crisis is looming.

‘To feed our growing population, we’ll need to double food production. Yet crop yields aren’t increasing fast enough, and climate change and new diseases threaten the limited varieties we’ve come to depend on for food. Luckily we still have the seeds and breeds to ensure our future food supply—but we must take steps to save them. . . .

‘Food varieties extinction is happening all over the world—and it’s happening fast. In the United States an estimated 90 percent of our historic fruit and vegetable varieties have vanished. Of the 7,000 apple varieties that were grown in the 1800s, fewer than a hundred remain. In the Philippines thousands of varieties of rice once thrived; now only up to a hundred are grown there. In China 90 percent of the wheat varieties cultivated just a century ago have disappeared. Experts estimate that we have lost more than half of the world’s food varieties over the past century. As for the 8,000 known livestock breeds, 1,600 are endangered or already extinct.’

Why is this a problem? Because if disease or future climate change decimates one of the handful of plants and animals we’ve come to depend on to feed our growing planet, we might desperately need one of those varieties we’ve let go extinct. . . .

‘It took more than 10,000 years of domestication for humans to create the vast biodiversity in our food supply that we’re now watching ebb away. Selectively breeding a wild plant or animal species for certain desirable traits began as a fitful process of trial and error motivated by that age-old imperative: hunger. . . .

‘Farmers and breeders painstakingly developed livestock breeds and food crops well suited to the peculiarities of their local climate and environment. Each domesticated seed or breed was an answer to some very specific problem—such as drought or disease—in a very specific place. The North American Gulf Coast Native sheep, for example, thrives in high heat and humidity and has broad parasite resistance. On the remote Orkney Islands, North Ronaldsay sheep can live on nothing but seaweed. Zebu cattle are more resistant to ticks than other cattle. In Ethiopia a small, humpless, short-horned cattle breed called the Sheko is a good milk producer that withstands harsh conditions and has resistance to sleeping sickness.

‘Such adaptive traits are invaluable not only to local farmers but also to commercial breeders elsewhere in the world. Finnsheep, for example, long raised only by a small group of Finnish peasants, have become vital to the sheep industry because of their ability to produce large litters. The Fayoumi chicken, an indigenous Egyptian species dating back to the reign of the pharaohs, is in great demand as a prodigious egg layer with high heat tolerance and resistance to numerous diseases. Similarly, the rare Taihu pig of China is coveted by the world’s pig breeders for its ability to thrive on cheap forage foods and its unusual fertility, regularly producing litters of 16 piglets as opposed to an average of 10 for Western breeds. . . .

‘[T]he green revolution was a mixed blessing. Over time farmers came to rely heavily on broadly adapted, high-yield crops to the exclusion of varieties adapted to local conditions. Monocropping vast fields with the same genetically uniform seeds helps boost yield and meet immediate hunger needs. Yet high-yield varieties are also genetically weaker crops that require expensive chemical fertilizers and toxic pesticides. The same holds true for high-yield livestock breeds, which often require expensive feed and medicinal care to survive in foreign climates. The drive to increase production is pushing out local varieties, diluting livestock’s genetic diversity in the process. As a result, the world’s food supply has become largely dependent on a shrinking list of breeds designed for maximum yield: the Rhode Island Red chicken, the Large White pig, the Holstein cow. In short, in our focus on increasing the amount of food we produce today, we have accidentally put ourselves at risk for food shortages in the future. . . .

‘Current efforts to increase food production in the developing world—especially in Africa, largely bypassed by the green revolution—may only accelerate the pace at which livestock breeds and crop species disappear in the years to come. In pockets of Africa where high-yield seeds and breeds have been introduced, the results have been mixed at best. Countries like Zimbabwe, Zambia, and Malawi ended up sacrificing much of their crop diversity to the monocropping of imported, high-yield varieties subsidized by government programs and provided by aid organizations. Small farmers and pastoralists have gone deep into debt to pay for the “inputs”—the fertilizers, pesticides, high-protein feeds, and medication—required to grow these new plants and livestock in different climate conditions. They are like addicts, hooked on a habit they can ill afford in either economic and ecological terms.

‘One response to the rapidly dwindling biodiversity in our fields has been to gather and safely store the seeds of as many different crop varieties as we can before they disappear forever. . . .

‘Today there are some 1,400 seed banks around the world. The most ambitious is the new Svalbard Global Seed Vault, set inside the permafrost of a sandstone mountain on the Norwegian island of Spitsbergen just 700 miles from the North Pole. Started by Cary Fowler in conjunction with the Consultative Group on International Agricultural Research, the so-called doomsday vault is a backup for all the world’s other seed banks. Copies of their collections are stored in a permanently chilled, earthquake-free zone 400 feet above sea level, ensuring that the seeds will remain high and dry even if the polar ice caps melt.

‘Fowler’s Global Crop Diversity Trust recently announced what amounts to a recapitulation of Vavilov’s worldwide seed-gathering expeditions: a ten-year initiative to scour the Earth for the last remaining wild relatives of wheat, rice, barley, lentils, and chickpeas in order to “arm agriculture against climate change.” The hope is that this mad-dash scramble will allow scientists to pass along the vital traits of these rugged relatives, such as drought and flood tolerance, to our vulnerable crop varieties.

‘Still, storing seeds in banks to bail us out of future calamities is only a halfway measure. Equally worthy of saving is the hard-earned wisdom of the world’s farmers, generations of whom crafted the seeds and breeds we now so covet. Perhaps the most precious and endangered resource is the knowledge stored in farmers’ minds. . . .

‘The challenge has been to show it’s possible to increase productivity without sacrificing diversity. . . . Keith Hammond, a UN expert on animal genetics, says that in 80 percent of the world’s rural areas the locally adapted genetic resources are superior to imported breeds.

‘. . . Preserving food diversity is only one of many strategies we’ll need to meet that challenge, but it is a crucial one. As the world warms, and the environment becomes less hospitable to the breeds and seeds we now rely on for food, humanity will likely need the genes that allow plants and animals to flourish in, say, the African heat or in the face of recurring blight. . . .’

Read the whole article in the National Geographic: Food ark, July 2011.


Filed under: Agriculture, Biodiversity, Food security, Indigenous Breeds, PA Tagged: Cary Fowler, CGIAR, Global Crop Diversity Trust, Keith Hammond, National Geographic Magazine, Sheko cattle breed, Svalbard Global Seed Vault, Zebu

An African cattle disease, disease-resistant cow and disease control solution

The tsetse fly, which spreads the livestock disease trypanosomosis

The tsetse fly, which spreads the livestock disease trypanosomosis (photo credit: ILRI/Elsworth).

Aid Netherlands has picked up news of a paper published last month in a leading scientific journal about a breakthrough in determining the genes responsible for controlling a tsetse fly-transmitted disease of livestock that has devastated Africa, and held back farming on the continent, for millennia. The paper was written by scientists at the International Livestock Research Institute (ILRI), in Nairobi, Kenya, and at partner institutes in the UK and Ireland.

‘New research published by an international research team in Proceedings of the National Academy of Sciences (PNAS) and using a new and intensive combination of approaches has found two genes that may prove of vital importance to the lives and livelihoods of millions of farmers in a tsetse fly-plagued Africa.

‘ILRI estimates that the annual economic impact of “nagana,” (officially known as African animal trypanosomiasis), stands at US$4–5 billion.

‘The research which merged a range of high-tech tools and field observations, sought to find biological answers to protection from a single-celled trypanosome parasite that causes both African sleeping sickness in people and the wasting nagana disease in cattle.

‘Tsetse fly carries the trypanosomes parasites which cause both sleeping sickness in humans, and the similar disease, nagana in cattle. Trypanosomiasis is endemic in much of Africa. Both nagana and sleeping sickness are fatal without treatment and quick interventions. Alphonce Laveran won the 1907 Nobel Prize for medicine for outlining his strategies for controlling sleeping sickness and nagana. While many countries in the continent have put in place measures to combat tsetse flies the reservoir of parasites in wild populations of wildlife such as antelope and buffaloes is large, and the disease remains difficult to control.

‘It is estimated that courtesy of increased surveillance and control in the last 13 years (1998–2009) sleeping sickness in people has dropped from 300,000 to 30,000. In that duration it has killed more than half of those infected.

‘“The two genes discovered in this research could provide a way for cattle breeders to identify the animals that are best at resisting disease when infected with trypanosome parasites, which are transmitted to animals and people by the bite of infected tsetse flies,” said senior author Steve Kemp, a geneticist on joint appointment with the Nairobi-based International Livestock Research Institute (ILRI) and the University of Liverpool.

‘According to disease mapping scientists and economists at ILRI the tsetse fly belt across Africa, stretches from “Senegal on the west coast to Tanzania on the east coast, and from Chad in the north to Zimbabwe in the south. Annually the disease renders millions of cattle too weak to plow land or to haul loads, and too sickly to give milk or to breed, before finally killing off most of those infected. This means that in much of Africa, where tractors and commercial fertilizers are scarce and prohibitively expensive, cattle are largely unavailable for tilling and fertilizing croplands or for producing milk and meat for families. The tsetse fly and the disease it transmits are thus responsible for millions of farmers having to till their croplands by hand rather than by animal-drawn plow.”

‘This international research on the hereditary norms of disease resistance research brought together scientists from the Africa, Europe and Asia. It was led by scientists from the Nairobi-based ILRI , universities of Liverpool, Manchester and Edinburgh, and drew the input of researchers from other institutions in Britain, Ireland and South Korea.

‘For the first time the international team that made this breakthrough did so by amalgamating multiple ranges of genetic approaches. Hitherto this had been done in isolation and separately.

‘“This may be the first example of scientists bringing together different ways of getting to the bottom of the genetics of a very complex trait,” says Kemp. “Combined, the data were like a Venn diagram overlaying different sets of evidence. It was the overlap that interested us.”

‘The key informant of the research was a humpless West African breed called the N’Dama. Much of African cattle especially the Boran breed are susceptible to disease-causing trypanosome parasites. N’Dama, on the other hand is not seriously affected by the disease as it was domesticated in Africa some 8,000 or more years ago and as such has had time to evolve resistance to the parasites.

‘Even though the N’Dama is a valued asset in the continent’s endemic regions it is characteristically small in size and produces less milk. However its disease resistant attributes is what many farmers would want transmitted to more productive breeds. N’Dama disease resistant gene has been the “Holy Grail” for international livestock geneticists for more than 20 years.

‘Genetic approaches to distinguish differences between the West African N’Dama, and Boran cattle, which come from Kenya, in East Africa were used at intervals to look for differences in those sequences between the two breeds. The Edinburgh team conducted gene expression analyses investigating differences in genetic activity of the two cattle breeds after sets of animals of both breeds were experimentally infected with the parasites. The ILRI group tested selected genes in the lab. Finally, they looked at the genetics of cattle populations from all over Africa.

‘“We believe the reason the N’Dama do not fall sick when infected with trypanosome parasites is that these animals, unlike others, have evolved ways to control the infection without mounting a runaway immune response that ends up damaging them,” said lead author Harry Noyes, of the University of Liverpool. “Many human infections trigger similarly self-destructive immune responses, and our observations may point to ways of reducing such damage in people as well as livestock.”

‘According to Kemp this new research which advances our understanding of genes that allow Africa’s N’Dama cattle to fight animal trypanosomiasis buttresses the importance of maintaining as many of Africa’s indigenous animal and breeds as possible.’

See this article in Aid Netherlands Opinion-Column-Blog: Indigenous answer to ‘nagana fly’ finally found, 20 June 2011.

Watch below a short (5-minute) film, ‘Battling a Killer Cattle Disease’, produced by ILRI, that provides background and context for this research breakthrough.

http://blip.tv/play/AYLAs3cC


Filed under: Africa, Agri-Health, Animal Diseases, Article, Biotech, Cattle, CRP4, Disease Control, Genetics, Health (human), ILRI, Indigenous Breeds, PA Tagged: Aid Netherlands Blog, Boran, Harry Noyes, N'Dama, PNAS, Sleeping sickness, Steve Kemp, Trypanosomosis, University of Edinburgh, University of Liverpool, University of Manchester

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