ILRI news

New approach to Rift Valley fever outbreaks aims to ensure food safety as region boosts livestock imports from Africa (photo credit: ILRI/Dolan)

With increased trade in livestock products offering a possible antidote to high food prices, livestock experts from the Middle East and 12 African countries are meeting this week (13-16 June, 2011) in Dubai to develop a strategy that eliminates the need to impose devastating bans on livestock imports from the Horn of Africa, as prevention against the spread of Rift Valley fever. The strategy should expedite the flow of livestock products while increasing safety of the overall livestock trade in the region.

Convened by the African Union’s Interafrican Bureau for Animal Resources (AU-IBAR), the International Livestock Research Institute (ILRI) and the United States Agency for International Development (USAID), the workshop will encourage officials and livestock traders to use a simple ‘Decision Support Planning Tool’ to guide and moderate their responses to Rift Valley fever outbreaks.

The ‘decision support tool’ for Rift Valley fever was developed by 30 experts and decisions-makers from across the Horn of Africa with technical assistance from researchers at ILRI, the United Nations’ Food and Agriculture Organization (FAO), and other partners. The tool will be used by chief veterinary officers and other national decision-makers. Its framework identifies the sequence of events likely to occur as the risk of a disease outbreak increases.

Rift Valley fever is a mosquito-borne virus found in eastern, western and southern Africa, Yemen and Saudi Arabia. Epidemics emerge periodically with prolonged rains. Climate and land-use changes could make outbreaks more frequent. A study done by ILRI economists Karl Rich and Francis Wanyoike indicated that the Rift Valley fever outbreak in 2007 cost Kenya at least USD32 million.

‘We must avoid unnecessary disruptions in agricultural trade between East Africa and the Middle East,’ said Ahmed El Sawalhy, director of AU-IBAR. ‘Livestock products must be safe and action concerning disease outbreaks must be in line with the actual threat.’ To this end, an animal health certification model suitable for pastoral livestock production systems and that promotes OIE standards has been developed by AU-IBAR in partnership with FAO and the Royal Veterinary College, London. The model is based on risk assessment and involves integration of both upstream animal health inspection and certification at entry points, markets and at the quarantines.

Time is also of critical importance in prevention and control of transboundary animal diseases. ‘In the last Kenyan Rift Valley fever outbreak, control measures were implemented late—not until there were definitive signs of an outbreak,’ said Jeffrey Mariner, an epidemiologist at ILRI. ‘This tool links early warning signs to control measures that can be implemented before animals or people begin falling ill. The new tool could reduce the impact of Rift Valley fever, and maybe even prevent some local outbreaks and has the potential to prevent the spread of Rift Valley fever through trade.’

‘The good news,’ says Bernard Bett, an epidemiologist at ILRI, ‘is that the impact of Rift Valley fever can be mitigated with early action during an outbreak, but veterinary officers and  decision-makers need to know what interventions to implement—and when—as the  stages of an epidemic  unfold.’

Rift Valley fever is best prevented through animal vaccination. But vaccines are expensive and few governments are willing to pay for expensive vaccines unless evidence indicates an epidemic is imminent. Regional cooperation is required to build consensus on managing the disease and to prevent trade disruptions.

Larry Meserve, USAID/EA’s regional mission director commented, ‘President Obama’s Feed the Future initiative aims to increase food security throughout Africa. To succeed, we must all help to improve the capacity of leadership in the Horn of Africa to anticipate potentially disastrous events like disease epidemics so that appropriate preventive or mitigating measures are taken before it is too late. Livestock is a vital staple crop in this part of the world, and both the private and public sectors have to do everything possible to prevent unnecessary disruptions in the trade of livestock and other commodities.’

Visit the official workshop blog site: http://rvfworkshop2011.wordpress.com

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Cow suffering from trypanosomiasis (photo credit: ILRI/Elsworth).

An international research team using a new combination of approaches has found two genes that may prove of vital importance to the lives and livelihoods of millions of farmers in a tsetse fly-plagued swathe of Africa the size of the United States. The team’s results were published today in the Proceedings of the National Academy of Sciences (PNAS).

The research, aimed at finding the biological keys to protection from a single-celled trypanosome parasite that causes both African sleeping sickness in people and a wasting disease in cattle, brought together a range of high-tech tools and field observations to address a critical affliction of some of the world’s poorest people.

With increased surveillance and control, sleeping sickness infections in people have dropped ten-fold in the last 13 years, from an estimated 300,000 cases a year in 1998 to some 30,000 in 2009, with the disease eventually killing more than half of those infected. Although best known for causing human sleeping sickness, the trypanosome parasite’s most devastating blow to human welfare comes in an animal form, with sick, unproductive cattle costing mixed crop-livestock farmers and livestock herders huge losses and opportunities. The annual economic impact of ‘nagana,’ a common name in Africa for the form of the disease that affects cattle (officially known as African animal trypanosomiasis), has been estimated at US$4–5 billion.

In a vast tsetse belt across Africa, stretching from Senegal on the west coast to Tanzania on the east coast, and from Chad in the north to Zimbabwe in the south, the disease each year renders millions of cattle too weak to plow land or to haul loads, and too sickly to give milk or to breed, before finally killing off most of those infected. This means that in much of Africa, where tractors and commercial fertilizers are scarce and prohibitively expensive, cattle are largely unavailable for tilling and fertilizing croplands or for producing milk and meat for families. The tsetse fly and the disease it transmits are thus responsible for millions of farmers having to till their croplands by hand rather than by animal-drawn plow.

‘The two genes discovered in this research could provide a way for cattle breeders to identify the animals that are best at resisting disease when infected with trypanosome parasites, which are transmitted to animals and people by the bite of infected tsetse flies,’ said senior author Steve Kemp, a geneticist on joint appointment with the Nairobi-based International Livestock Research Institute (ILRI) and the University of Liverpool.

This genetics of disease resistance research was led by scientists from ILRI in Africa and from the UK universities of Liverpool, Manchester and Edinburgh, and involved researchers from other institutions in Britain, Ireland and South Korea.

The researchers drew on the fact that while the humped cattle breeds characteristic of much of Africa are susceptible to disease-causing trypanosome parasites, a humpless West African breed, called the N’Dama, is not seriously affected by the disease. Having been domesticated in Africa some 8,000 or more years ago, this most ancient of African breeds has had time to evolve resistance to the parasites. This makes the N’Dama a valued animal in Africa’s endemic regions. On the other hand, N’Dama cattle tend to be smaller, to produce less milk, and to be less docile than their bigger, humped cousins.

African agriculturalists of all kinds would like to see the N’Dama’s inherent disease resistance transferred to these other more productive breeds, but this is difficult without precise knowledge of the genes responsible for disease resistance in the N’Dama. Finding these genes has been the ‘Holy Grail’ of a group of international livestock geneticists for more than two decades, but the genetic and other biological pathways that control bovine disease resistance are complex and have proven difficult to determine.

The PNAS paper is thus a landmark piece of research in this field. The international and inter-institutional team that made this breakthrough did so by combining a range of genetic approaches, which until now have largely been used separately.

‘This may be the first example of scientists bringing together different ways of getting to the bottom of the genetics of a very complex trait,’ said Kemp. ‘Combined, the data were like a Venn diagram overlaying different sets of evidence. It was the overlap that interested us.’

They used these genetic approaches to distinguish differences between the ‘trypano-tolerant’ (humpless) N’Dama, which come from West Africa, and ‘trypano-susceptible’ (humped) Boran cattle, which come from Kenya, in East Africa. The scientists first identified the broad regions of their genomes controlling their different responses to infection with trypanosome parasites, but this was insufficient to identify the specific genes controlling resistance to the disease. So the scientists began adding layers of information obtained from other approaches. They sequenced genes from these regions to look for differences in those sequences between the two breeds.

The team at Edinburgh conducted gene expression analyses to investigate any differences in genetic activity in the tissues of the two cattle breeds after sets of animals of both breeds were experimentally infected with the parasites. Then, the ILRI group tested selected genes in the lab. Finally, they looked at the genetics of cattle populations from all over Africa.

Analyzing the vast datasets created in this research presented significant computational challenges. Andy Brass and his team in the School of Computer Science at the University of Manchester managed to capture, integrate and analyze the highly complex set of biological data by using workflow software called ‘Taverna,’ which was developed as part of a UK e-Science initiative by Manchester computer scientist Carole Goble and her ‘myGrid’ team.

‘The Taverna workflows we developed are capable of analyzing huge amounts of biological data quickly and accurately,’ said Brass. ‘Taverna’s infrastructure enabled us to develop the systematic analysis pipelines we required and to rapidly evolve the analysis as new data came into the project. We’re sharing these workflows so they can be re-used by other researchers looking at different disease models. This breakthrough demonstrates the real-life benefits of computer science and how a problem costing many lives can be tackled using pioneering E-Science systems.’

To bolster the findings, population geneticists from ILRI and the University of Dublin examined bovine genetic sequences for clues about the history of the different breeds. Their evidence confirmed that the two genes identified by the ILRI-Liverpool-Manchester groups were likely to have evolved in response to the presence of trypanosome parasites.

‘We believe the reason the N’Dama do not fall sick when infected with trypanosome parasites is that these animals, unlike others, have evolved ways to control the infection without mounting a runaway immune response that ends up damaging them,’ said lead author Harry Noyes, of the University of Liverpool. ‘Many human infections trigger similarly self-destructive immune responses, and our observations may point to ways of reducing such damage in people as well as livestock.’

This paper, said Kemp, in addition to advancing our understanding of the cascade of genes that allow Africa’s N’Dama cattle to fight animal trypanosomiasis, reaffirms the importance of maintaining as many of Africa’s indigenous animal breeds (as well as plant/crop varieties) as possible. The N’Dama’s disease resistance to trypanosome parasites is an example of a genetic trait that, while not yet fully understood, is clearly of vital importance to the continent’s future food security. But the continued existence of the N’Dama, like that of other native ‘niche’ African livestock breeds, remains under threat.

With this new knowledge of the genes controlling resistance to trypanosomiasis in the N’Dama, breeders could screen African cattle to identify animals with relatively high levels of disease resistance and furthermore incorporate the genetic markers for disease resistance with markers for other important traits, such as high productivity and drought tolerance, for improved breeding programs generally.

If further research confirms the significance of these genes in disease resistance, a conventional breeding program could develop a small breeding herd of disease-resistant cattle in 10–15 years, which could then be used over the next several decades to populate Africa’s different regions with animals most suited to those regions. Using genetic engineering techniques to achieve the same disease-resistant breeding herd, an approach still in its early days, could perhaps be done in four or five years, Kemp said. Once again, it would be several decades before such disease-resistant animals could be made available to most smallholder farmers and herders on the continent.

‘So it’s time we got started,’ said Kemp.

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See this news and related background material at ILRI’s online press room.

The International Livestock Research Institute (www.ilri.org) works with partners worldwide to help poor people keep their farm animals alive and productive, increase and sustain their livestock and farm productivity, and find profitable markets for their animal products. ILRI’s headquarters are in Nairobi, Kenya; we have a principal campus in Addis Ababa, Ethiopia, and 13 offices in other regions of Africa and Asia. ILRI is part of the Consultative Group on International Agricultural Research (www.cgiar.org), which works to reduce hunger, poverty, illness and environmental degradation in developing countries by generating and sharing relevant agricultural knowledge, technologies and policies. This research is focused on development, conducted by a Consortium (http://consortium.cgiar.org) of 15 CGIAR centres working with hundreds of partners worldwide, and supported by a multi-donor Fund (www.cgiarfund.org).

The University of Liverpool (www.liv.ac.uk) is a member of the Russell Group of leading research-intensive institutions in the UK. It attracts collaborative and contract research commissions from a wide range of national and international organizations valued at more than £110 million annually.

The University of Manchester (www.manchester.ac.uk), also a member of the Russell Group, is the largest single-site university in the UK. It has 22 academic schools and hundreds of specialist research groups undertaking pioneering multi-disciplinary teaching and research of worldwide significance. According to the results of the 2008 Research Assessment Exercise, the University of Manchester is now one of the country’s major research universities, rated third in the UK in terms of ‘research power’. The university has an annual income of £684 million and attracted £253 million in external research funding in 2007/08.

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An ILRI-Wellcome project is investigating the disease pathogens circulating in both people and animals in the communities outside the border town of Busia, Kenya, where smallholders mix crop growing with livestock raising (photo credit: ILRI/Pye-Smith).

A project funded by the Wellcome Trust on zoonotic diseases was broadcast last week on an Australian television program called ‘Catalyst’. The show ran on Thursday, 10 March 2011, at 20:00 Australian time. The research described in the program is supported by the International Livestock Research Institute (ILRI), where the project’s principal investigator, Eric Fevre, is hosted.

The television program interviews Fevre and his colleagues Lian Doble, a veterinarian managing laboratory work in western Kenya, and  Appolinaire Djikeng, technology manager of a Biosciences eastern and central Africa (BecA) Hub, located on ILRI’s Nairobi, Kenya, campus.

Fevre and Doble and their team are investigating what disease pathogens of both people and animals are circulating near the border town of Busia, a very poor, densely populated area whose communities mix crop growing with livestock raising on small plots of land. Research such as this that is looking at both human and animal diseases is rare but urgently needed because the close relations of people and farm animals in many poor regions, as well as the existence of monkeys and other wildlife nearby, is a ‘recipe for diseases’ jumping from animals to people. If we’re going to manage to forestall another zoonotic plague such as bird flu or HIV/AIDS, we’re going to have to conduct more of such ‘one health’ investigations that look at exactly what diseases are being transmitted between animals and people. The research project in western Kenya is part of a larger study being conducted by the BecA Hub to look at diseases of animals and people across eastern Africa. The BecA Hub team is using genomics and meta-genomics, and ’4 million bucks of computing power,’ to build a picture of the complex relations of disease pathogens circulating in the region.

Eric Fevre, who leads the ILRI-Wellcome project investigating the disease pathogens circulating in both people and animals in Busia, points out a pit latrine frequented by pigs as well as people, where disease transmission between the two species is most likely to occur (photo credit: ILRI/Pye-Smith).

A transcript of the Australian television program on this research follows.

NARRATION
Africa, the cradle of humanity and renowned for its wildlife. It could also be the origin of the next global pandemic. It’s long been known that people and animals living close together—well, that’s a recipe for disease. But exactly which diseases? And if new diseases are creeping into the system? Well, that’s something they’re trying to find out here in western Kenya. They’re called zoonotic diseases: infections that can jump from animals to people.

Eric Fevre
There are lots of zoonotic infections. In fact, about 60 per cent of all human diseases are of zoonotic origin.

NARRATION
So this team headed by Eric Fevre is taking a much closer look at the health of people and livestock in a densely populated region of western Kenya.

Eric Fevre
It seems to be obvious that zoonotic infections will occur more in people who keep livestock than in those who don’t. Whether that’s the case has never been formally established.

Lian Doble
If you look around here you don’t see the cattle in a field, in a fenced field or in a barn away from the people. Cattle are tethered within the compound that everybody’s working in, the chickens are loose around, going in and out of the houses. It’s a much more integrated system than anything we really see at home.

NARRATION
The kinds of problems that this environment creates are readily apparent.

Eric Fevre
We’re in a mixed crop-livestock production system where people are keeping a few animals. And as you can see behind me here, it’s the rainy season and people have recently planted their new crops. And this is an area of interaction between the croplands and the animals. And you can see behind over there behind those fields is some forest. And there might be a watercourse flowing through that forest, for example, where the animals are going to water. And that’s where the exciting things happen from a disease transmission point of view.

NARRATION
Part of the team focus on human health, taking a range of samples from people in the village as well as a detailed account of their medical history and current living situation. Meanwhile, others in the team have a look at the livestock.

Lian Doble
What we do know is that there are a large number of diseases that circulate between animals and humans. The problem is that a lot of these diseases cause signs which are very similar to other human diseases like malaria and human tuberculosis. What isn’t known is actually how many of the diseases that are mainly diagnosed as malaria actually are another disease caused by the pathogens found in cattle. So we’re just trying to find out what diseases she has and what are shared with the people that she lives with.

Paul Willis
And does she look healthy?

Lian Doble
She’s feisty and she’s quite healthy so we’ll see what she might have been carrying. And we can tell you later in the lab.

NARRATION
Samples are taken back to field laboratories in the town of Busia on the Ugandan border.

The ILRI-Wellcome Trust animal-human laboratory in Busia, Kenya (photo credit: ILRI/Pye-Smith).

Eric Fevre
In this place we’ve got a human and an animal lab next door where we process the material that comes in from the field. One of the things that we really need to do is look at fresh material. Because once the samples get a bit old, the parasites become a bit difficult to identify. And the second important thing is that we of course feed back to the participants of our study. So results that we get in the lab here are used directly by the clinicians working in the field to decide what treatments they should be giving people. So that’s one of the direct ways that our research project feeds back into the community.

NARRATION
This detailed look at the community health of a whole region is showing many expected results, and a few surprises.

Eric Fevre
One of the diseases that we’re testing for is brucellosis. And looking at the official reports there isn’t any brucellosis in this region. But we have detected brucellosis both in animals and in people and so already that’s what’s telling us that there are things circulating here that official records don’t pick up.

NARRATION
There seems to be a lot of malaria around, but Eric’s team are finding that many cases are masking something much more sinister.

Eric Fevre
Often it won’t be malaria. It will be something else. And there are a multitude of different pathogens that cause fever of the type that malaria also causes. And that’s a real problem. Because somebody with a low income might need to, say, sell one of their animals to then go to the clinic, get a diagnosis, buy some anti-malarial drugs. They don’t work because the person actually has sleeping sickness. So they go back to a different clinic. Or to a traditional healer. They get drugs that don’t work for the infection that they have. And so on and so on, five, six, seven times, travelling maybe ten kilometres each time. That’s a huge economic burden on them. And then finally they get properly diagnosed when they’re in the late stage of their infection. And it would have been much easier to treat them if they’d have been caught earlier on.

NARRATION
It’s a very complex picture that is emerging, one that could be simplified by some basic technology.

Lian Doble
Thirty per cent of our participants don’t have access to a latrine. You can imagine what that means. And that’s something that could be very actually quite easily sorted out with some education and some money and would sort out all sorts of other diarrhoeal diseases, which are one of the huge killers of young children in Africa.

One of the ultra-modern laboratories at the Biosciences eastern and central Africa (BecA) Hub ‘platform’ hosted and managed by ILRI in Nairobi, Kenya (photo credit: ILRI/White).

NARRATION
Back in Nairobi another team is taking a different look at the spread of diseases across east Africa.

NARRATION
Appolinaire Djikeng heads up a team collecting samples of animals and people from a wide swath across Kenya.

Appolinaire Djikeng
So essentially at the moment we are trying to cover the east African region. But of course we would like to once we establish our processes and data management skills and data analysis skills we like to expand this to other parts of Africa.

NARRATION
The first step in the labs is to figure out exactly what spread of diseases are present in their samples.

Appolinaire Djikeng
You are able to go in there, look at the, the complex composition of the viruses, at the pathogens or at the small organisms that exist in them in doing it that way you are able to come up with a catalogue of potential organisms that exist in there.

NARRATION
And this analysis goes deep into the DNA of the viruses and pathogens that are found, tracking minute changes in their genetic make-up that allows Appolinaire’s team to follow the spread of individual strains of a disease.

Appolinaire Djikeng
We have a reasonably good bioinformatic infrastructure here for storing that data and extracting them, looking at specific parameters from that particular data base. With so many samples from such a wide geographical area and with so much information for each individual sample these guys are dealing with a lot of data and so they brought in four million bucks worth of computing grunt. With so many samples from such a wide geographic area and with so much information for each individual sample these guys are dealing with a lot of data. So they brought in four million bucks worth of computing grunt.

NARRATION
There are several teams looking at zoonotic diseases in Kenya, but the impact of their work is global.

Appolinaire Djikeng
The threat of emerging and re-emerging infectious diseases are no longer restricted to countries like central Africa or sub-Saharan Africa So I think now we have to put this work in the context of the global effort across the world. Trying to make sure that even remote parts of the area do have resources and capabilities to begin to do good and accurate diagnostics of what could be emerging.

Eric Fevre
We actually use the data that we gather to, to try and understand how these things are being transmitted, how the fact that your animal has this disease impacts on your risk at a population scale. And, and use that to then try and understand the, the process of transmission of these diseases.

Lian Doble
The next big disease problem is very likely to be a zoonotic disease so doing this sort of work and then leaving it isn’t an option. It needs to be ongoing and, and build. This is the start of something and we’ll build on it from here.

Download this Catalyst show from Australia’s ABC website (select ‘Zoonosis’ 10/3/2011).

And check out a blog by Paul Willis about the adventures of filming in Kenya’s border town of Busia: Coming to an end, 7 March 2011.

Here’s some of what Paul Willis has to say in his blog about this film project:
‘Busia is a hard place; a border crossing town riddled with grinding poverty and hard living. The main street, the only sealed road through town, is frequently clogged with a seemingly endless string of trucks waiting to cross the border into Uganda. Because Uganda, Rwanda and Burundi are all landlocked nations, every drop of fuel and most freight coming into the country has to be trucked in from Mombasa and most of that comes through Busia. . . . This area of Kenya has some of the most intensively farmed land in East Africa. The whole landscape is divided into small plots with clusters of mud and thatch huts scattered among them. Here people live cheek-by-jowl with their crops and animals. It’s a recipe for diseases to jump from animals to people. Add strips of forested vegetation inhabited by a variety of monkeys and other native mammals and the chances of new diseases leaping into the human population goes up dramatically. We’re here to report on the work of a dedicated group trying to get a handle on exactly what diseases are in this chaotic system. It’s hard work, in one of the hotter areas of Kenya, and the study is spread over a huge area. . . .’

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A small-scale dairy farmer with her cows in Uganda. A new three-year project will identify and make available appropriate dairy cows for smallholders in East Africa to help them increase their milk yields (photo credit: EADD).

A new project identifying appropriate dairy breeds for small-scale farmers in East Africa, and making these breeds more available in the region, was launched in February 2011 at the Nairobi campus of the International Livestock Research Institute (ILRI). The Dairy Genetics East Africa project—a partnership between ILRI; the University of New England, in Australia; and PICOTEAM, a consultancy group facilitating change processes—will help smallholders obtain the most appropriate cows for their farms so as to increase their milk yields and improve their livelihoods.

Speaking to dairy stakeholders from Kenya, including officials from Kenya’s Ministry of Livestock Development, the East Africa Dairy Development (EADD) project and other dairy industry development partners, at the launch on 9 February 2011, Okeyo Mwai, a researcher and the project’s coordinator at ILRI, explained that even though smallholder dairying is booming in parts of East Africa, such as in Kenya’s central region and the north and southern Rift Valley areas, where farmers have adopted improved animal breeds and intensified milk production, many more smallholders lack research-based knowledge about which dairy breeds are best suited for their farms and production systems and information about where to obtain them. According to Mwai, ‘Kenya’s dairy sector currently does not have a clear “breeding strategy.”’ That means that many poor smallholders are unable to take advantage of breeds that best suit their situations.

In the absence of appropriate breeding strategies and the ready supply of appropriate replacement stock, farmers face an unpredictable, unreliable and often costly replacement processes. Many are forced to replace their animals from their existing animals or from their neighbours. Others go to large-scale commercial farms and end up ‘upgrading’ to the main commercial dairy breeds even where these don’t suit their farms.

This project will determine the breed composition of cows currently kept in the project areas, the breeds smallholders prefer and the reasons for their preferences, and which breeds perform best under specific conditions. ‘This information will help us assess the relative fit of the various breeds to different production systems,’ says Ed Rege, a team leader at PICO. ‘We’ll then develop partnerships and business models with the private sector to breed, multiply and continuously supply the best-performing dairy breeds to farmers at affordable prices.’

The project will be implemented in five sites in western Kenya and three sites in Uganda. The first phase of the project will start with gathering information to assess the relative performance of breeds in the sites, setting up partnerships with other stakeholders in dairy development in the region and developing business models that will be carried out the later (phase 2 and 3) stages of the project.

In the first phase, project staff will collect information on about 3000 cows based on two monthly farm visits made over a period of 18 months. Field agents will compile information on the performance of the cows vis-vis farm-level inputs for a cost-benefit analysis of the different breeds. The agents will also collect information on farmer-perceived risks associated with different breeds, on means of livelihoods of the farmers, on any gender-specific preferences for certain breeds, and on farmer use of the various breeding services available and their costs.

The breed compositions will be obtained using advanced genotyping technology, which will be led by John Gibson, the project’s principal investigator, who is based at Australia’s University of New England. This information will be combined with cow and household data to identify the most appropriate breeds for various dairy production systems and household circumstances.

‘This project will harness the diverse expertise of the key partners, and combine the latest technologies with tried and tested methods of engaging with the community, to answer critical questions much more rapidly and accurately than has been possible in the past,’ said Gibson, who formerly worked at ILRI as a livestock geneticist.

Participants in the meeting expressed their support for the project, noting its focus on cattle genetic improvement—an area that has received inadequate research attention in the region. Alex Kirui, country director of the non-governmental organization Heifer International, said the project’s focus on ‘giving farmers the right breed for given circumstances’ is an essential requirement if the dairy industry is to be competitive enough to meet the high and increasing regional demand for fresh milk and other dairy products. Moses Nyabila, regional director for the East Africa Dairy Development Project, said the project would ‘unlock the value of the cow, which is a key asset for smallholder farmers.’

Results from the project’s first phase will guide future dairy pilot studies in East Africa and will inform a comparative study of the South Asian dairy industry.

The project is funded by the Bill and Melinda Gates Foundation. It started in September 2010 and is scheduled to end early in 2013.

—

For more information visit: http://www.ilri.org/node/598

View presentations from the meeting

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In September 2010, four CGIAR Centers – CIAT, ICARDA, ILRI and WorldFish – formally submitted a proposal on ‘livestock and fish’ to the CGIAR Consortium Board (CB).

We just received feedback and guidance on the proposal. Overall, the Consortium Board “appreciates the innovations in this proposal, and its overall quality. The Board considers that, with a few additional improvements, the proposal will be ready to be submitted to the Fund Council.”

The Board and the reviewers also raise some important questions about our proposal: We need your help to respond to some of the critical questions raised by the reviewers:

Question 1: Can we really expect livestock and fish production ‘by the poor’ to contribute meaningfully to nutrition ‘for the poor’?

Question 2: How best to partner with the private sector in pro-poor livestock and fish value chain development?

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Left: A Hmong girl, 13-year-old Hi Hoa Sinh, holds a native black chicken in the village of Lung Pu, northern Viet Nam; Right: One of Viet Nam’s native black pigs on the farm of Ma Thi Puong, near the northern town of Meo Vac (photo credit: ILRI/Mann).

A project funded by the Global Environment Facility has selected Vietnam, a country with a wealth of livestock diversity, as one of four countries in which to implement a project to conserve livestock genotypes.

The diversity is deteriorating due to the popularization of new breeds together with the commercialization of livestock production. To preserve indigenous livestock breeds, the Global Environment Facility and the International Livestock Research Institute (ILRI) have selected 4 countries—Vietnam, Bangladesh, Pakistan and Sri Lanka—to implement the project ‘Developing and applying supporting tools on the conservation and sustainable utilization of the genetic diversity of livestock and their wild relatives.’

Vietnam’s Ministry of Agriculture and Rural Development has made the National Institute of Animal Husbandry as the Vietnamese partner in the project.

The project aims to enhance livestock keepers’ awareness of the importance of the genetic conservation of indigenous livestock while helping them to raise their incomes through adoption of indigenous livestock breeds. The project is being implemented over 4 years (2010–2012) in Vietnam’s Son La and Bac Ninh provinces, with a focus on indigenous chicken and pig breeds. The project will train farmers on survey methods and data collection; on ways to maintain their use of indigenous animals; on livestock management; and on business skills in such areas as as tourism with traditional cuisine and cultural activities.

Basic information about valuable indigenous breeds and representative animals is needed, as is the capacity to prioritize, monitor and manage them at both scientific and farm operational levels. Stakeholder groups need to be empowered with knowledge and conducive operational environments in which they can make decisions that work best for them.

Agriculture in the partner countries in this project contributes 20 to 26% of gross domestic product, of which livestock contributes approximately 15 to 20% in terms of income, insurance, food (meat, milk, eggs), hides/skin, traction and manure. It is mostly smallholder farmers who are dependent on indigenous breeds. These animals have evolved in diverse tropical environments and possess valuable traits such as disease resistance, adaptation to harsh environments, including heat tolerance and ability to utilize poor quality feeds, attributes essential for achieving sustainable agriculture in low-input production systems. However, it is still largely unknown which breeds hold significant genetic diversity or specific genes that should be targeted for conservation and/or incorporation into breeding programs. In the meantime, crossbreeding with exotic breeds is increasing and indigenous breeds are being lost.

The development objectives of this project are to help conserve the indigenous livestock of the partner countries for future generations and to help increase the contribution these native breeds make to the livelihoods of poor people. The first goal of the project is to develop and to make available effective tools to support decision making for the conservation and sustainable use of indigenous farm animals and their wild relatives in developing countries.

For more information, see the project’s description on ILRI’s Biotechnology Theme webpage.

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Tom Olaka, a community animal health worker in Karamajong, northern Uganda, was part of a vaccination campaign in remote areas of the Horn of Africa that drove the cattle plague rinderpest to extinction in 2010 (photo credit: Christine Jost).

A superb example of why technical breakthroughs matter is reported in the current issue (22 October 2010) of the leading science journal, Science.

The eradication of rinderpest from the face of the earth, probably the most remarkable achievement in the history of veterinary science, is a milestone expected to be announced in mid-2011 pending a review of final official disease status reports from a handful of countries to the World Organisation for Animal Health.

A plague of cattle and wild ungulates, rinderpest would not have been eradicated without such a technical breakthrough. This was the development of an improved vaccine that did not require a 'cold chain' and thus could be administered in some of the most inhospitable regions in the Horn of Africa, where the virus was able to persist due to lack of vaccination campaigns in these hotspots.

Rinderpest is a viral livestock disease that has afflicted Europe, Asia and Africa for centuries. It killed more than 90 per cent of the domesticated animals, as well as untold numbers of people and plains game, in Africa at the turn of the 19th century, a devastation so complete that its impacts are still felt today, more than a century later. The last-known outbreak of rinderpest occurred in Kenya in 2001.

The key technical breakthrough in this effort involved development of an improved vaccine against rinderpest. The original vaccine was developed at the Kenya Agricultural Research Institute (KARI) laboratories. In 1990, Jeffrey Mariner, a veterinary epidemiologist who at that time was at the Tufts Cummings School of Veterinary Medicine and working with the Africa Union-Inter-African Bureau for Animal Resources (AU-IBAR), improved the vaccine by producing a thermostable version that did not require refrigeration up to the point of use. This allowed vets and technicians to backpack the vaccine into remote war-torn areas, where vet services had broken down and international agencies dared not send personnel. The AU-IBAR led the Pan-African Rinderpest Campaign, which coordinated the efforts that resulted in the eventual eradication of rinderpest from Africa.

Now working in the Nairobi laboratories of at the International Livestock Research Institute (ILRI), Mariner says that just as important as this technological advance was getting the development community to begin to address how people work together. Mariner and his colleagues at AU-IBAR themselves took three innovations as lessons from the rinderpest eradication campaign: (1) community-based vaccination programs, (2) participatory surveillance systems based on local knowledge, and (3) optimized control strategies that target high-risk communities through.

‘We must examine issues from the perspective of each group of stakeholders involved and visualize how proposed changes would affect them,’ says Mariner. ‘The power relationships of the groups also need to be considered. Advocates for change must then craft a new vision for how the various stakeholder groups will function that is sufficiently exciting to get people to risk change.’

Excerpts from the Science article, by Dennis Normille, follow.
'Rinderpest, an infectious disease that has decimated cattle and devastated their keepers for millennia, is gone. The United Nations Food and Agriculture Organization (FAO) announced on 14 October in Rome that a 16-year eradication effort has succeeded and fieldwork has ended.

'“This is the first time that an animal disease is being eradicated in the world and the second disease in human history after smallpox,” FAO Director-General Jacques Diouf said in his World Food Day address in Rome the next day.

'“It is probably the most remarkable achievement in the history of veterinary science,” says Peter Roeder, a British veterinarian involved with FAO’s Global Rinderpest Eradication Programme (GREP) from its launch in 1994 until he retired in 2007. For the veterinarians who participated in the effort, the achievement is particularly poignant. . . .

'One formality remains: The Paris-based World Organisation for Animal Health (OIE) still must complete the certification of a handful of countries as rinderpest free. OIE is likely to adopt an official declaration recognizing the demise of the disease at its May assembly. Meanwhile, animal-disease fighters have already been applying lessons learned from the rinderpest campaign and pondering which animal disease might be the next target for eradication.

'Although nearly forgotten in much of the West, as recently as the early 1900s, outbreaks of rinderpest—from the German for “cattle plague”—regularly ravaged cattle herds across Eurasia, often claiming one-third of the calves in any herd. The virus, a relative of those that cause canine distemper and human measles, spreads through exhaled droplets and feces of sick animals, causing fever, diarrhea, dehydration, and death in a matter of days. It primarily affects young animals; those that survive an infection are immune for life.

'When the virus hit previously unexposed herds, the impact was horrific. In less than a decade after the virus was inadvertently introduced to the horn of Africa in 1889, it spread throughout sub-Saharan Africa, killing 90% of the cattle and a large proportion of domestic oxen used for plowing and decimating wild buffalo, giraffe, and wildebeest populations. With herding, farming, and hunting devastated, famine claimed an estimated one-third of the population of Ethiopia and two-thirds of the Maasai people of Kenya and Tanzania. . . .

'In 1994, when rinderpest was entrenched in central Africa, the Arabian Peninsula, and a swath stretching from Turkey through India and to Sri Lanka, FAO brought together three regional rinderpest-control programs into GREP and set the goal of eliminating the disease by 2010. . . .

'The key technical breakthrough was the recognition that the virus was re-emerging from just a handful of reservoirs that could be the targets of intensive surveillance and vaccination campaigns. In 1990, Jeffrey Mariner, then at Tufts University School of Veterinary Medicine (now the Cummings School of Veterinary Medicine), had developed an improved vaccine that did not require refrigeration up to the point of use. This allowed vets and technicians to backpack vaccine into remote areas. One of the reservoirs was in the heart of war-torn eastern Africa, where vet services had broken down and international agencies dared not send personnel. GREP relied on local pastoralists to track the disease and on trained community animal health workers to administer the vaccine to quell outbreaks.

'. . . The virus was last detected in 2001 in wild buffaloes in Meru National Park in Kenya, on the edge of the Somali ecosystem.

'What comes next? Some veterinary experts question whether the international community is ready to take on another massive eradication campaign, but one disease mentioned as a possible eradication target is peste des petites ruminants (PPR), which is highly contagious and lethal among sheep and goats. Related to the rinderpest virus, the PPR virus has long circulated in central Africa, the Middle East, and the Indian subcontinent and has recently spread to Morocco. . . .'

ILRI's Jeff Mariner is now working on an improved vaccine for this disease.

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Read the whole article at Science (registration needed to read the full article): Rinderpest, deadly for cattle, joins smallpox as a vanquished disease, 22 October 2010.

To find out what the eradication of rinderpest means for livestock farmers around the world, listen to the following interview featuring John McDermott, ILRI's deputy director general.

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Women and livestock in Niger: Leading scientists in African agriculture are gathering, this week, in Ethiopia, to discuss the challenges and opportunities of commercializing livestock agriculture in Africa (photo credit: ILRI/Mann)

As agricultural leaders across the globe look for ways to increase investments in agriculture to boost world food production, experts in African livestock farming are meeting in Addis Ababa this week to deliberate on ways to get commercialized farm production, access to markets, innovations, gender issues and pro-poor policies right for Africa’s millions of small-scale livestock farmers and herders.

More than 70 percent of Africa’s rural poor are livestock farmers. Each farm animal raised is a rare source of high-quality food, particularly of dietary protein, minerals, vitamins and micronutrients, for these households. Pastoralists, who rely on herding their animal stock to survive in the continent’s dry and otherwise marginalized environments, also make up a significant number of Africa’s population.

‘There is a growing recognition by governments and donors that expanding investment in the agricultural sector is a cornerstone for alleviating poverty and building assets in Africa and other developing regions,’ said Carlos Seré, director general of the International Livestock Research Institute (ILRI).

‘Smart investments targeting the developing world's growing numbers of livestock keepers (who make up about 1 billion people today) is a win-win-win,’ said Seré. ‘Such investments promise not only to greatly increase global food security but also to generate profits for both poor livestock producers and agribusinesses.’

Livestock production today employs more than 1.3 billion people globally. Most African small-scale farmers practice mixed farming systems that combine both crop farming and livestock keeping. Globally, these mixed systems produce the majority of the world’s food staples, including 89 percent of the maize, 91 percent of the rice, nearly 75 percent of the milk and 68 percent of the beef consumed.

Livestock-based enterprises are pathways out of poverty for many people in Africa, for whom animals are a source of nourishing foods and regular incomes. With demand for milk, meat and eggs rising fast in many developing countries, the raising and marketing of animals and animal products also allows many people to take advantage of the new growth opportunities in this sector.

Despite the vibrancy of the livestock sector in Africa, much of the investments in African agriculture for food security to date has focused almost exclusively on crop farming. That is a mistake, says Seré, as are many investments made to boost crop and livestock production systems independently.

A livestock scourge eradicated
This is an opportune time for a meeting of Africa’s leading livestock experts. On 16 October 2010, to mark the United Nations World Food Day, the Food and Agriculture Organization of the United Nations and other world bodies chose to celebrate the eradication of rinderpest from the face of the earth. Probably the most remarkable achievement in the history of veterinary science, this milestone is expected to be announced in mid-2011, pending a review of final official disease status reports from a handful of countries to the World Organisation for Animal Health.

Rinderpest is a viral livestock disease that has afflicted Europe, Asia and Africa for centuries. It killed more than 90 percent of the domesticated animals, as well as untold numbers of people and plains game, in Africa at the turn of the 19^th century, a devastation so complete that its impacts are still felt today, more than a century later. The last-known outbreak of rinderpest occurred in Kenya in 2001.

The key technical breakthrough in this effort involved development of an improved vaccine against rinderpest that did not require refrigeration up to the point of use. This allowed vets and technicians to backpack the vaccine into remote war-torn areas where the disease was a major problem. The AU-IBAR led the Pan-African Rinderpest Campaign, which coordinated the efforts that resulted in the eventual eradication of rinderpest from Africa.

Livestock conference to address main constraints to livestock production in Africa
It is against this background that leading scientists in African agriculture are gathering 25–28 October 2010 at the United Nation Conference Centre in Addis Ababa, Ethiopia, to discuss the challenges and opportunities of commercializing livestock agriculture in Africa at the Fifth All African Society of Animal Production.

Carlos Seré, director general of the International Livestock Research Institute, gives a keynote address during the opening of the fifth all African society of animal production (photo credit: ILRI/Habtamu)

Among specific areas to be addressed are livestock trade and markets, pastoralism and natural resource management, animal genetics and commercialization, climate change and its effects on livestock systems, livestock feeds, and the delivery of livestock services to smallholders and herders.

Despite its wealth of livestock resources, Africa produces livestock at relatively low levels, due to a range of technical, socioeconomic and biological challenges faced by smallholders and herders on the continent. These include weak policies and veterinary and other institutions; widespread parasitic, tropical and other livestock and zoonotic diseases; poor-quality feeds; inadequate inputs for livestock production; insufficient access to livestock markets and market information; and low market prices.

‘This conference is addressing policy and strategy gaps that have prevented African livestock producers from making the most of their livestock resources,’ said Tadelle Dessie, a scientist with ILRI. ‘Addressing these gaps should help raise the level of investment in livestock production and improve market access for small-scale livestock producers.’

Fix gender-based problems in livestock livelihoods
One potent way to enable Africa’s farmers and herders to benefit more from livestock production, say many who have researched the topic, is to redress gender imbalances in access to resources for livestock production. ‘Institutional, social and economic gender-based constraints inhibit women’s full participation in livestock markets and marketing,’ says Jemimah Njuki, a scientist with ILRI.

Research shows that many African women already have access to very local markets and that they already participate in different stages of livestock value chains. ‘Helping women access market-related information will help them help raise the continent’s livestock production levels,’ Njuki said, adding, ‘and should allow them to benefit more from their livestock enterprises.’

Watch a short video interview with Carlos Seré: http://www.youtube.com/watch?v=FIFiQJp-WaY

View presentations from the conference: http://www.slideshare.net/tag/esap

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The Farm Animal Genetic Resources Project is encouraging wider use of native Asian chicken, goat and pig breeds to help sustain the livelihoods of poor farmers (photo credit: ILRI) 

A Farm Animal Genetic Resources Project conducted by the International Livestock Research Institute (ILRI) and other partners to conserve indigenous livestock breeds in Bangladesh, Pakistan, Sri Lanka and Vietnam has been recognized by the United Nations Environment Programme (UNEP) as one of eleven global projects ‘assisting farmers in developing diversified and resilient agricultural systems to ensure communities and consumers have more predictable supplies of nutritious food.’

The ILRI project is featured in an UNEP booklet launched on Tuesday 19 October 2010 during the tenth meeting of the Conference of the Parties to the Convention on Biological Diversity, taking place in Nagoya, Japan.

Securing sustainability through conservation and use of agricultural biodiversity: The UNEP-GEF contribution provides lessons from projects about useful tools for conserving and managing agricultural biodiversity over the long term. The report features project partnerships among UNEP, the Global Environment Facility (GEF) and national and international organizations conducted over the last 10 years.

The ILRI-led and GEF-funded US$6.4-million Farm Animal Genetic Resources Project was started in 2009 to better conserve local breeds of chickens, goats and pigs that help sustain the livelihoods of poor farmers and the health and well-being of women and children in Asia.

As much as 10 per cent of the world’s livestock breeds have disappeared in the last six years, due mostly to substitution or cross-breeding of local indigenous animals with exotic commercial breeds. Most of the extant indigenous livestock breeds today are found in pastoral herds and on small farms in developing countries. Understudied and insufficiently documented, many of the strengths and potential benefits of these tropical local breeds remain untapped.

The Farm Animal Genetic Resource Project works to encourage wider use of local breeds, such as the Bengal goat in Bangladesh. Each of the four countries where the project is implemented has a long history of use of indigenous livestock and a rich diversity of animals, including the wild relatives of domestic livestock, which provide additional genetic resources for breeding programs to improve domestic animals.

ILRI’s project partners include the Bangladesh Agricultural University; the Pakistan Agricultural Research Council; the University of Peradeniya, in Sri Lanka; and the Vietnamese National Institute of Animal Husbandry, with more organizations expected to join the project later. By the time the project is completed, in 2014, these partners aim to have developed breeding tools for use in low-input livestock production systems, cost-benefit analysis tools for comparing breeding programs for different indigenous breeds and populations, and analytical frameworks for assessing policy and marketing options for farm animal genetic resources.

So far, with the input of local actors, including farmers, researchers and development agents, the Farm Animal Genetic Resources Project has developed baseline survey tools for assessing animal genetic biodiversity and constraints to its conservation. These tools will also be used to assess marketing opportunities for indigenous animals and the contributions these animals make to rural livelihoods. The project has also developed a flock and herd monitoring tool that helps to measure genetic and phenotypic diversity, to track genetic changes in livestock populations over time, and to capture the relations between indigenous domesticated animals and their wild relatives.

Mohamed Ibrahim, ILRI’s coordinator of this Asia project, says that the project is increasing the capacity of local institutions to collect and analyse data related to indigenous livestock breeds. ‘Our goal,’ says Ibrahim, ‘is to ensure that important chicken, goat and pig breeds in the four targeted Asian countries are protected for the future benefit of local farmers’.

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Read the complete report on the following link: http://www.unep.org/dgef/Portals/43/AgBD_publication_FINAL.pdf

And find out more about the Farm Animal Genetic Resources Project on their website: http://www.fangrasia.org; and partner websites: www.fangrbd.org, www.fangrvn.org

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