ILRI News

Public-private partnership makes major step towards improving livestock health and reducing poverty.

The devastating effects of East Coast fever on the livelihoods of small-scale farmers may one day be a thing of the past as a team of international scientists moves closer towards the development of a vaccine.

“East Coast fever is an intractable problem that ravages cattle of the poor in Africa. The good news is that this can be solved by high-tech science and technological innovations, achievable through strategic partnerships’’. Evans Taracha – ILRI East Coast Fever Vaccine Project Leader

Every year, East Coast fever destroys the small farmer’s dream of escaping poverty in Africa. Killing more than a million cattle and costing some $200 million annually, this tick-borne disease rages across a dozen countries in eastern and central Africa. Now, an international team of scientists has taken the first major step toward a vaccine to prevent East Coast fever. Their work, published in the February 13-17 early online edition of the Proceedings of the National Academy of Sciences (PNAS), shows how genomics can generate pivotal new vaccines.

In the study, scientists from five institutions, including the International Livestock Research Institute (ILRI) and The Institute for Genomic Research (TIGR), identify five vaccine targets, or candidate proteins that could form the basis for an East Coast fever subunit vaccine. Based on combined bioinformatics analyses and lab tests, these proteins appear to provide a protective immune response to the disease. “This initiative took just three years, after many years of scientists trying other methods,” remarks Vishvanath Nene, former ILRI staff member, a study author and molecular biologist at TIGR. “It’s a huge jump forward.”

To make the jump, researchers used the genome sequence of the parasite responsible for East Coast fever. A tick-borne parasite, Theileria parva, causes the disease. When ticks infected with T. parva bite cattle, they transmit the parasite, launching the disease that typically kills cattle within a month. In July, 2005, TIGR led a research team that published T. parva’s genome sequence, representing roughly 4,000 genes, in Science.

In the current study, Nene, along with Malcolm Gardner and Claire Fraser-Liggett, also of TIGR, relied on known biology to search T. parva’s genome for potential vaccine proteins. First, scientists know that immunity to the parasite, and thus East Coast fever, emerges from immune system cells known as killer T cells. Second, they know that T. parva is an intracellular pathogen–it infects and secretes proteins inside cattle white blood cells, which become malignant. The white blood cell then unwittingly passes small fragments of the secreted parasitic proteins associated with a certain type if its own proteins along to its cell surface. And this is where a vaccine could come in: A vaccine made of the T. parva proteins found on the surface of host cells should trigger an immune response in cattle. Vaccinated cattle would then be protected from the parasite.

To find potential vaccine antigens, the TIGR researchers scanned T. parva’s entire genome for genes that make secreted proteins. In particular, they searched for genes that make a “secretion signal,” a telltale peptide sequence found at the start of secreted proteins. Sure enough, the scientists found some 400 T. parva genes containing the secretion signal. This set of genes provided a starting pool of candidate proteins. Based on further tests, the study’s research team, led by ILRI of Nairobi, Kenya, cloned 55 candidate antigen genes and screened those genes for response by killer T cells taken from cattle immune to East Coast fever. To complement TIGR’s gene selection strategy, ILRI also incorporated a random screen of T. parva DNA for vaccine candidates.

In total, the team found five candidate vaccine antigens. In lab tests, these antigens triggered a response from cattle immune killer T cells. Going a further step further, the scientists inoculated cattle with these antigens and then gave the cattle a potentially lethal dose of T. parva. When compared with control animals, vaccinated cattle showed significantly stronger immune response to the parasite.

“This study is a true milestone,” says Fraser-Liggett, president of TIGR. “It’s one of the first to take advantage of genomic technologies and build a test vaccine using immune killer T cells as a screening reagent.” In addition to TIGR and ILRI, the research team included scientists from: the Ludwig Institute for Cancer Research in Brussels; the Wellcome Trust Center for Human Genetics in Oxford; Sanofi Pasteur in Toronto; the University of Edinburgh; and Merial SAS, an international animal health company. ILRI and Merial have partnered to develop a vaccine against East Coast fever.

By using genomics to understand and fight T. parva, scientists may make advances against related parasites that cause malaria, tuberculosis, and other diseases in which killer T cells also play a role in immunity. What’s more, because T. parva launches a cancer-like illness inside the white blood cells of cattle, it may provide a model system for understanding the mechanics of cancer biology.

But for Nene, who was born in Kenya and worked at ILRI for 15 years before coming to TIGR in 2001, the march against East Coast fever is significant reward, itself. “This disease takes an enormous toll on the local society and economy of rural areas across eastern and central Africa, including Maasai and other pastoral communities,” he says. In particular, East Coast fever kills cattle kept by families trying to rise out of poverty. If researchers are successful, Nene notes, the entire region will have new reason to hope for a better life. Evans Taracha, ILRI project leader, also highlights the importance of strategic research partnerships to overcome this and similar diseases.

TIGR’s portion of the PNAS study was funded independently by TIGR and by sub-contract from the Animal Health Program of the United Kingdom Department for International Development, with previous contributions from J. Craig Venter and the ILRI for the T. parva genome project.

Group of 25 experts enters 'uncharted waters' in building futuristic livestock scenarios that force new thinking and new decisions.

The International Livestock Research Institute (ILRI) and the Food and Agriculture Organization of the United Nations (FAO) hosted a group of 25 livestock and futures experts from around the world for two and a half days 13–15 February 2006 to do some non-crystal-ball-gazing. The experts constructed alternative scenarios of likely futures of livestock development in developing countries, paying particular attention to what will happen to poor people.

They got help from, Jerome Glenn, who is an expert in ‘futures research’ and director of a think tank called the Millennium Project, which has been running under the aegis of the American Council for the United Nations University since 1991.

Decision-makers in ILRI and FAO and other livestock research and development institutions are the target of the products of this meeting. The idea behind this work is to force serious, flexible thinking about alternative possibilities for the future and begin to come up with the right mix of strategic decisions that will allow people to adapt to the future. The process of doing this work can alter the way decision makers think about the future. That, says Glenn, may be the most important outcome of the meeting.

‘The germ of a future-oriented collective intelligence on livestock development for the poor was created here,’ Glenn said at the close of the meeting. ‘What we believe is possible for livestock development is “pretty poultry”’, he punned. ‘Here, for example, are just a few of the things that were not yet in the world in 1980: personal computers, the World Wide Web, cellular phones, AIDS, the European Union and the World Trade Organisation. The world has changed dramatically in the last 25 years. What is guaranteed is that we will have even more and faster changes in the future. This meeting was held to enlarge the capacity of stakeholders in livestock development to respond to good and bad events in future, including major shocks such as another tsunami, a war and or disease pandemics.’

Click here to read Jerome Glenn’s paper, Global Scenarios and Implications for Constructing Future Livestock Scenarios, January 2006, 68 pages.

‘We are entering uncharted waters’, said FAO Henning Steinfeld, to develop a platform for creating a better understanding of livestock futures.’

ILRI’s director general, Carlos Seré, said ILRI and FAO share concerns about finding the best ways to position livestock in a dynamic world for the benefit of the poor.

The products of this meeting include a wealth of information embedded in four plausible ‘storylines’ that the participants constructed for the future. The participants adapted the Millennium Ecosystem Assessment scenarios for the livestock sector and used two axis: one defining a future  environmentally reactive or proactive, the other defining a future globalized or fragmented. The scenarios the ILRI-FAO meeting participants developed ranged from a ‘Techno-Garden’, where technology is largely a good, benefiting many and bringing people together, to ‘Global Orchestration’, a world where consumers rule—but which consumers?, to an ‘Adaptive Mosaic’ future in which novel uses of IT connect livestock communities, to ‘Order from Strength; Weakness from Chaos’, a future in which where today’s international organizations are largely ineffective or have disappeared altogether, the world is fragmented and reactionary, and its every country for itself.

Summaries of the storylines will be produced by the end of March 2006. A longer report will be produced subsequently by ILRI and FAO. To receive a copy of the summaries or report, contact the meeting’s organizers, ILRI’s Ade Freeman or FAO’s Anni McLeod.

This livestock expert opinion is needed to feed into a major inter-governmental and consultative 3-year effort initiated by the World Bank called the International Assessment of Agricultural Science and Technology for Development. Involving 900 participants and 110 countries, the IAASTD is now collecting global and regional assessments of the state and needs of science and technology and is at the stage of preparing first drafts of results. Results of the ILRI-FAO meeting will also be used to inform annual program meetings of ILRI and the Animal Production and Health Division of FAO, where feedback from wider circles of livestock experts will be sought.

The aim of all this work, says ILRI livestock systems analyst Philip Thornton, is to ‘help build and drive a bandwagon rather than jumping on whatever bandwagon happens along. We need to be changing mindsets in a world where ten percent of the world’s population consumes ninety percent of the world’s resources. It is surely not impossible to have a more equitable world. We need to show people that livestock are a great development tool with which to do that.’

FAO Henning Steinfeld agrees. ‘The livestock sector must respond to the world as it is—and to how the sector is likely to be in the foreseeable future.’

If the world does not view livestock experts as long-term global visionaries, maybe it should take another look.

Marc Lacey of The New York Times reports on the drought and bad planning that are hurting East Africa's drylands.
 
‘Animals are dying in huge numbers, their rotting carcasses littering the landscape and devastating the local economy. Aid workers estimate that 70 percent of the 260,000 cows in Kenya's Wajir district, near the border with Somalia, have died. Goats and sheep also are dying. Even camels, known for their ability to endure the most rugged of conditions, are dropping in the sand.’

People and livestock continue to die of thirst in the drought ravaged northern part of Kenya, despite having water delivered to them twice a week. This is because the water is barely enough to cater for all the individual members of the communities living here. At 20 litres of water a week, this averages to about three glasses of water per person, per day, for drinking and all other household purposes.

Click here to read the full article.

Click here for more from ILRI on the drought in Africa.

ILRI vaccine developers won an award for Outstanding Scientific Article. Another ILRI team conducting research on savannah ecosystems shared an award for their innovative collaboration with Maasai landowners in Kenya.
 
Scientific Recognition

Each year, the Consultative Group on International Agricultural Research (CGIAR) recognizes the scientific contributions of the 15 agricultural research centres it supports through its Science Awards, presented at its Annual General Meeting (AGM), held each year in December.

At the CGIAR’s AGM held in Washington DC at the end of last year, scientists from ILRI and The Institute for Genomic Research (TIGR) picked up the award for ‘Outstanding Scientific Article’ for their paper, published in the top scientific journal Science, ‘Genome Sequence of Theileria parva: a Bovine Pathogen that Transforms Lymphocytes’. The team, led by Malcolm Gardner of TIGR, received a cash prize of US$10,000, which is being donated to fund travel for staff and students to attend conferences in this area.

The paper’s second author, ILRI scientist Richard Bishop, said: “We are delighted to receive this award. Our multi-partner collaboration and recent discoveries illustrate that African science is forging ahead – we are collaborating with world-class players and producing world-class science right here in Africa, for Africa.”

Pictured above from left to right: ILRI’s Director of Research, John McDermott, and TIGR scientist (and former ILRI staff member) Vish Nene, with the Award for ‘Outstanding Scientific Paper’. Looking on is ILRI’s Director General Carlos Seré and Bruce Scott, ILRI Director, Partnership and Communications.

Download TIGR/ILRI Press Release

Innovative Collaboration with Civil Society

The CGIAR also recognizes the contributions of innovative collaborations between CGIAR-supported centres and Civil Society Organizations (CSOs) through its ‘Innovation Marketplace Awards’. This year, 46 CSOs were invited to participate at the CGIAR Innovation Marketplace to showcase their collaborative work and share experiences.

 ILRI’s collaboration with the Kitengela Ilparakuo Landowners Association (KILA) was one of four collaborations to win a Judges’ Award with a cash prize of US$30,000, to use for further collaborative work. ILRI has been collaborating with the Maasai of Kitengela Plains, located next to Nairobi National Park, in Kenya, since 2002. They have devised means to ensure that people, livestock and wildlife can live in harmony and have lobbied government to reduce fencing to allow the annual migration of wildlife though the Kitengela Plains, thus helping to prevent conflicts between wildlife and people and their livestock. Other collaborators of the program are Kenya Wildlife Service, Friends of Nairobi National Park, The Wildlife Foundation and Kajiado County Council.

The prize award was collected by ILRI’s CSO representative Ogeli Ole Makui and ILRI’s Mohammed Said. Makui said: “This award means so much to us. Our major challenge is to move forward and continue with the collaboration to help the community move forward. The Landowners Association will be using the prize money to fund further collaborative work.

Pictured above, from left to right: CGIAR Chair and Vice President of the World Bank Kathy Siena, the Program Officer of the Kitengela Land Lease Program, Ogeli Ole Makui and ILRI scientist Mohammed Said.

Download the award-winning poster

ILRI Awards

Dr Carlos Seré , ILRI’s Director General, said: “ILRI’s work is frequently recognized at the CGIAR’s annual awards. Each year the bar is raised and this year was no exception. Competition was tough with a very high standard of entries in all categories. We wish to extend our congratulations to the winners from our sister centres and are delighted that ILRI has won two of the top awards this year. This recognizes our commitment and contributions to both science and society.”

Pictured above from left: ILRI Directors Carlos Seré and Bruce Scott and the President of the World Bank, Paul Wolfowitz at the CGIAR exhibit booth at the AGM in December 2006 in Washington, DC.

Highly valued livestock waste away in the drought-hammered Horn of Africa.
 
Livestock in the thousands are dying daily in a drought ravaging Kenya and its neighbours in the Horn of Africa.Animals are in the news everywhere these days in the Horn of Africa. While disease control agents are on the look-out for sick or dead chickens, to spot what could be bird flu and prevent its spread, everyone else is fixed on a more daily sight: that of starving cattle wandering city streets in desperate search of grass. When too feeble to walk, the animals lay down to die.

Just five years ago, Kenyans were appalled by images from the UK of mass slaughter of hundreds of
thousands of cattle to stop the spread of foot-and-mouth, a disease endemic in Kenya and much of the developing world, where its appearance hardly raises a stir. Maasai pastoralists in particular thought the British crazy as well as cruel to kill so many and such valuable animals and offered to buy them from the ‘mad Englishmen’.

But the daily spectacle of cattle, sheep and goats dying across the parched countryside and in the city centres and leafy suburbs of towns and cities in the drought-hammered Horn may be even harder to bear. Livestock are valued highly here; they are the basis of livelihoods of most poor rural people, who, in the annual dry seasons, lose weight along with their farm animals. But these countries are too poor to deploy bullets for mercy killings. So animals die here like the poorest people do, slowly, painfully and in full view of everyone.

Debate on Africa's food crisis
Click here to read a debate 'Head-to-head: Africa's food crisis', from BBC News between Nicholas Crawford, an official from the UN's World Food Programme (WFP) and Tajudeen Abdul-Raheem, a pan-Africanist and Director of Justice Africa, on what is causing Africa's deepening food crisis and what the solutions might be.

For more, please go to:
Bird flu threatens countries already in crisis
Avian flu and the developing world
Killing drought hits the Horn of Africa
Climate change threatens tropical maize production
Serious rain: Feature story
‘Healing Wounds’ in the Horn of Africa
Innovative livestock-water project launched