The Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub plays a pivotal role in fostering an ecosystem conducive for scientists from National Agricultural Research Systems, the CGIAR and advanced research institutes from the global north to tackle significant agricultural challenges in Africa. By offering access to cutting-edge technologies, comprehensive knowledge, mentorship and technology incubation and deployment, the hub aims to empower researchers to develop homegrown solutions that contribute significantly to food and nutrition security across the continent. This vision is carried out through four connected pillars, namely, innovations, translational research and product development, all underpinned by the pillar on institutional and professional development. These pillars serve as the foundation for cultivating a robust scientific community capable of generating sustainable solutions to agricultural challenges, thereby enhancing the livelihoods of millions and securing the future of food supply in Africa.