vaccines

This page brings together ILRI and partner resources on vaccines. Click different tabs to see news items, research outputs, journal articles, video materials and presentations as well as ILRI projects and people related to vaccines. See ILRI research on other subjects

The ECF consortium is aiming at producing a vaccine that would trigger both an antibody response and a T cell dependent response. Thanks to the whole genome sequence of Theileria parva and its annotation, we have short listed hundreds of antigen candidates, but the number of antigen candidate that can be tested in cattle is limited. How do we narrow down the list of candidates to a handful that can be studied rigorously in live experiments? Continue reading →
ILVAC - saving livestock with vaccines, Dec/2016
The recent meeting of the East Coast fever consortium, which brings together experts in immunology, parasitology and genomics from three continents (ILRI, Edinburgh, Antwerp, IGS, as well as the organization that produces the infection and treatment method (ITM) vaccine, provided a venue to discuss a way forward. Continue reading →
ILVAC - saving livestock with vaccines, Nov/2016
As part of a BMGF-funded consortium a novel Next-generation-sequencing (NGS) approach to high-throughput MHC typing of cattle has been developed that allows rapid, cheap and high resolution characterisation of bovine MHC genotypes Continue reading →
ILVAC - saving livestock with vaccines, Nov/2016
Tanzania has been reported to have the third largest livestock population on the African continent comprising 25 million cattle. However, cattle keepers in the country face several challenges that impede their productivity, most notably diseases. As such, access to effective methods of preventing, controlling and/or treating cattle diseases is key. East Coast Fever (ECF) is … Continue reading →
ILRI Livelihoods, Gender and Impact, Nov/2016
A recent review, as well as current studies in the primary literature, present examples of how cancer research can be used in the study of Theileria biology, suggesting that this might be a turning point that could revolutionize how T. parva infection is studied. Continue reading →
ILVAC - saving livestock with vaccines, Nov/2016
We are here aiming to directly identify the parts or 'antigens' of the Theileria parva parasite that are visible to the cellular immune system during infection using a state-of-the-art mass spectrometry approach in order to inform the development of targeted vaccines against Theileriosis. Continue reading →
ILVAC - saving livestock with vaccines, Nov/2016
The partial success of subunit vaccine candidates based on sporozoite proteins give rise to the belief that sporozoite surface antigens might constitute neutralizing vaccine candidates. This milestone together with the protective immunity of whole sporozoite infection and treatment vaccination can be further built upon in order to ultimately achieve protection against ECF infection with a multivalent subunit vaccine. Continue reading →
ILVAC - saving livestock with vaccines, Nov/2016
In the last 9 years, yeast has been tested as a way to help immune cells see and react to human pathogens such as hepatitis C virus, and cancer. Yeast has also helped chickens survive coccidiosis and pigs survive porcine circovirus infection. We are now persuading yeast to wear a coat decorated with T. parva trophies and train cattle immune cells to react appropriately (in this case to kill T. parva). Continue reading →
ILVAC - saving livestock with vaccines, Nov/2016
Antigen screening studies indicate that CD8 T cells from immune cattle recognise a large number of T. parva proteins, but whether or not CD8 T cells specific these proteins are all equally capable of mediating protection is not known. The lack of an antigen delivery system known to be capable of inducing protective CD8 T cell responses represents an obstacle to answering this important question. Continue reading →
ILVAC - saving livestock with vaccines, Oct/2016
The WSU monoclonal antibody (mAb) center was established in 1982 with a focus on developing mAb reagents for use in research. It became a formal service center of the Washington State University and CVM in 2012. Continue reading →
ILVAC - saving livestock with vaccines, Sep/2016

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Elise Schieck
PostDoc
Maureen Lorna Atieno Otieno
Research technician
Naftaly Githaka
Tick Unit Support Officer
Nicholas Svitek
Scientist (Immunologist-Virologist)
Theo Knight-Jones
Epidemiologist/Food safety expert - Post-doctoral fellow

Video

People working on vaccines

Elise Schieck
PostDoc
Maureen Lorna Atieno Otieno
Research technician
Naftaly Githaka
Tick Unit Support Officer
Nicholas Svitek
Scientist (Immunologist-Virologist)
Theo Knight-Jones
Epidemiologist/Food safety expert - Post-doctoral fellow