Nicholas Svitek

Personal Information
Staff picture Full name Nicholas Svitek
Position Scientist (Immunologist-Virologist)
Email N.Svitek@cgiar.org
Telephone +254 20 422 3426
Profile

Dr. Nicholas Svitek joined the ILRI Vaccine Biosciences (ILVAC) team February 1st 2014 as a cellular immunologist after completing a 3-year postdoctoral fellowship, in the same group, on reverse vaccinology and the cellular immunity towards Theileria parva in cattle. Prior to this, Nicholas had been working at Duke-National University of Singapore (NUS) in the Emerging Infectious Diseases (EID) department as a research fellow in virology. Nicholas holds a Bachelor of Science (B.Sc.) degree in Biological Sciences from the University of Montreal, a Master of Science (M.Sc.) degree in Microbiology and Immunology from that same university, and a Philosophiae Doctor (Ph.D.) degree in Virology and Immunology from the University of Quebec where his research was conducted at the Institut Armand-Frappier (IAF), a member institute of the "Institut Pasteur International Network". Nicholas brings to ILRI many years of experience studying viral infections and viral pathogenesis in animal models, more specifically on viruses member of the Reoviridae and Paramyxoviridae families. Nicholas’ research interests are in the immune responses towards vaccines and infectious pathogens, virus-host interactions, vaccine/antigen delivery systems and on the biology and pathogenesis of emerging viruses.

 

List of publications:

1. Svitek N., Hansen A.M., Steinaa L., Saya R., Awino E., Nielsen M., Buus S., Nene V. (2014). Use of “One-Pot, Mix-and-Read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle. Veterinary Research.  doi:10.1186/1297-9716-45-50.

2. Nene V., Svitek N., Toye P., Golde W.T., Barlow J., Buss S., Nielsen M. (2012). Designing Bovine T-Cell Vaccines Via Reverse Immunology. Ticks and Tick-Borne Diseases. 3(3):188-192.

3. Svitek N., Gerhauser I., Goncalves C., Grabski E., Döring M., Kalinke U., Anderson D.E., Cattaneo R., von Messling V. (2014). Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but not STAT1 for Canine Distemper Virus Virulence in Ferrets. Journal of Virology. 88:2941-2950.

4. Maines T.R., Belser J.A., Gustin K.M., van Hoeven N., Zeng H., Svitek N., von Messling V., Katz J.M., and Tumpey T.M. (2012). Local Innate Immune Responses and Influenza Virus Transmission and Virulence in Ferrets. Journal of Infectious Diseases. 205:474-485.

5. Rouxel R.N., Svitek N. and von Messling V. (2009). A Chimeric Measles Virus with Canine Distemper Envelope Protects Ferrets from Lethal Distemper Challenge. Vaccine 27:4961-4966.

6. Pillet S., Svitek N. and von Messling V. (2009). Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines. Curr Top Microbiol Immunol. 330:73-87.

7. Svitek N., Rudd P.A., Obojes K., Pillet S. and von Messling V. (2008). Severe Seasonal Influenza in Ferrets Correlates with Reduced Interferon and Increased IL-6 Induction. Virology 376:53-59.

8. Svitek N., and von Messling V. (2007). Early Cytokine mRNA Expression Profiles Predict Morbillivirus Disease Outcome in Ferrets. Virology 362:404-410.

9. von Messling V., Svitek N. and Cattaneo R.. (2006). Receptor (SLAM [CD150]) Recognition and the V Protein Sustain Swift Lymphocyte-Based Invasion of Mucosal Tissue and Lymphatic Organs by a Morbillivirus. Journal of Virology. 80: 6084-6092.

Communications at International Conferences:

Oral presentations

  1. Svitek N., Saya R., Pelle R., Nene V., Steinaa L. (2014). Identification of the determinants required for MHC class I-binding and TCR recognition in two polymorphic CTL epitopes from Theileria parva. 12th Biennial Conference of the Society for Tropical Veterinary Medicine (STVM) and the VIII International Conference on Ticks and Tick-Borne Pathogens (TTP-8). Cape Town, SOUTH AFRICA.
  2. Svitek N., Steinaa L., Saya R., Awino E., Hansen A., Nielsen M., Buus S., Nene V. (2013). Novel Peptide-MHC Tetramers to Characterize the Specificity of the CD8+ T Cell Response against Theileria parva. 15th International Congress of Immunology, Milan, ITALY.
  3. Svitek N., Steinaa L., Saya R., Awino E., Hansen A., Nielsen M., Buus S., Nene V. (2013). Novel “On-Demand” Peptide-MHC Tetramers to Characterize the Specificity of the CD8+ T Cell Response against Theileria parva. 10th International Veterinary Immunology Symposium, Milan, ITALY.
  4. Nene V., Svitek N., Toye P., Buus S., Nielsen N., Golde W., and Barlow J. (2011). Designing Bovine T-cell Vaccines Via Reverse Immunology. Seventh Ticks and Tick-Borne Pathogens International Conference, Zaragoza, Spain.
  5. Svitek N., and Nene V. (2011). Immunoinformatics and Reverse Vaccinology, Potential Application to Development of an African Swine Fever Virus Vaccine. African-Swine Fever Workshop, Nairobi, Kenya.
  6. Goncalves C., Svitek N., Cattaneo R., and von Messling V. (2010). STAT1-Independent V Protein-Mediated Block of Mx Transcription is Essential for Canine Distemper Virulence. American Society for Virology Annual Meeting, Montana, USA.
  7. Svitek N., Cattaneo R., and von Messling V. (2009). V Protein-Mediated Block of Mx Transcription is Essential for Morbillivirus Virulence. Tri-Society Meeting, Cellular and Cytokine Interactions in Health and Disease, Lisbon, Portugal.
  8. Svitek N., Cattaneo R., and von Messling V. (2008). The Cysteine-Rich Domain of the CDV V Protein is Essential for Virulence in Ferrets but Not to Block the Interferon Signaling Cascade. American Society for Virology Annual Meeting, Ithaca, USA.
  9. Svitek N., and von Messling V. (2007). Characterizing the Role of Canine Distemper Virus V Protein Domains in Immunosuppression. American Society for Virology Annual Meeting, Corvalis, USA.
  10. von Messling V., Rudd P.A., Obojes K., Pillet S., Svitek N. (2007). Immune Responses to Non-Lethal Human Influenza Strains in Ferrets. American Society for Virology Annual Meeting, Corvalis, USA.
  11. Svitek N., Cattaneo R., and von Messling V. (2006). Morbilliviruses Control the Immune System Response by Interfering with Cytokine Induction. American Society for Virology Annual Meeting, Madison, USA.
  12. Svitek N., Fernandes S., and Lemay G. (2004). Role of Reovirus σ1 Protein Glycosidase Activity in the Viral Life Cycle. ACFAS Annual Meeting, Montreal, Quebec, Canada.

Poster presentations

  1. Svitek N., Hansen A. M., Steinaa L., Saya R., Awino E., Nielsen M., Buus S., Nene V. (2013). Immunoinformatics and MHC-Tetramers, Revolutionary Technologies for Vaccine Development. ILRI Annual Program Meeting [APM], Addis Ababa, ETHIOPIA.
  2. Svitek N., Michuki G., Pelle R., Nielsen M., Buus S., Nene V. (2012). Immunodominance in Theileria parva Infection, Strategies to Identify Peptides That Elicit a Strong CTL Response. 5th Congress of the Federation of Immunological Societies of Asia Oceania (FIMSA) 2012, New Delhi, India.
  3. Svitek N., Goncalves C., Cattaneo R., and von Messling V. (2010). Canine Distemper Virus Virulence is Independent of Interference With STAT1-Signaling Pathways. SingHealth Duke – NUS Scientific Congress 2010, Singapore, Singapore.
  4. Svitek N., Cattaneo R., and von Messling V. (2009). V Protein-Mediated Block of Mx Transcription is Essential for Morbillivirus Virulence. Tri-Society Meeting, Cellular and Cytokine Interactions in Health and Disease, Lisbon, Portugal.
  5. Bastien L.E., Rudd P.A., Svitek N., and von Messling V. (2009). Cytokine Profiles in Epithelial and Immune Tissues of Ferrets Infected with Lethal or Attenuated CDV Strains. American Society for Virology Annual Meeting, Vancouver, Canada.
  6. Svitek N., Cattaneo R., and von Messling V. (2007). Morbillivirus Immunosuppression Determinants. Measles Virus Mini-Symposium, Mayo Clinic, Rochester, MN, USA.
  7. Svitek N., Fernandes S., and Lemay G. (2004). Role of Reovirus σ1 Protein Glycosidase Activity in the Viral Life Cycle. American Society for Virology Annual Meeting, Montreal, Canada.

 

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