Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen

Journal Article
Published on
bySpringer

Abstract

In this report, we describe the cloning, sequencing, and expression of the bovine orthologue of CD26 (BoCD26). Several monoclonal antibodies specific for a molecule, activation molecule 3 (ACT3), aberrantly expressed on superantigen-stimulated bovine CD8+ lymphocytes, reacted with recombinant BoCD26 expressed in COS-7 and CHO cells. We also showed that human CD8+ T cells stimulated by a superantigen expressed CD26 at high levels. These results demonstrate that ACT3 is identical to BoCD26 and suggest that CD26 upregulation on CD8+ T cells is a general phenomenon of superantigens and not limited to their effects on bovine cells.

Citation

Immunogenetics;54 (3): 216-220

Authors

  • Sang-Un Lee
  • Young-Ho Park
  • Davis, W.C.
  • Hamilton, M. Jo
  • Naessens, Jan
  • Bohach, G.A.

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