Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva

Abstract

Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future.

Citation

Parasite Immunology;22(5): 223-230

Authors

  • Hall, R.
  • Boulter, N.R.
  • Brown, C.G.D.
  • Wilkie, G.
  • Kirvar, E.
  • Nene, Vishvanath M.
  • Musoke, A.J.
  • Glass, E.J.
  • Morzaria, S.P.